Result: Also, eight genomes were classified in the Marseille-501/A.27 lineage that was first detected in our institute in January 2021, accounted for 18 genomes in our database and which may or may not harbour Q677H substitution.
Result: Codon changes from CAG to CAT or CAC leading to this Q677H substitution deoptimise the viral codon usage relative to that of the human genome.
Result: Finally, viral neutralisation in the presence of a monoclonal conformation-dependent antibody targeting the spike receptor binding domain led to a 50% reduction in neutralisation of 677H-harbouring spike relative to 677Q-harbouring spike (wild type), and of Q677H/D614G-harbouring spike
Multiple SARS-CoV-2 Variants Exhibit Variable Target Cell Infectivity and Ability to Evade Antibody Neutralization.
Discussion: The P681H, P681R, and Q677H mutation sites in the variants are located near the furin cleavage site, which may affect the cleavage of S protein.
SARS-CoV-2 Delta (B.1.617.2) Variant: A Unique T478K Mutation in Receptor Binding Motif (RBM) of Spike Gene.
Bioinformatic analysis of the whole genome sequences of SARS-CoV-2 from Indonesia.
PMID: 34540148
2021
Iranian journal of microbiology
Abstract: Beside D614G mutation, we report three unique mutations: A352S, S477I, and Q677H.
Result: Meanwhile, we recorded three unique mutations at A352S, S477I, and Q677H.
Result: Mutation Q677H was found firstly in Surabaya on April 2020 (EPI_ISL_437188), then three months later it was found in Jawa Barat, in two different samples (EPI_ISL_518751 and EPI_ ISL_518759) in July 2020.
Result: The alignment of Q677H is showed in.
Result: The position of Q677H is the S1 domain, relatively close to S1/S2 junction.
Table: Q677H
Figure: (c) Site mutation of PMID: 34700382
2021
mBio
Result: Dual mutants containing D614G and other amino acid changes, including those under positive selection or observed in VOCs (L5F, L18F, S98F, W152L/C, E154K, L222V, and A262S in S1-NTD; N439K, L452Q/R, S477N, L478R/K, E484K/Q, N501Y, and A570D within S1-RBD; Q677H/P and P681H/R in S1-CTD; T716I,
Variants of SARS-CoV-2, their effects on infection, transmission and neutralization by vaccine-induced antibodies.
PMID: 34604978
2021
European review for medical and pharmacological sciences
Abstract: S477N, E484K, Q677H, E484Q, L452R, K417T, K417N and N501Y.
Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants.
Discussion: Although the lineage P.6 was substituted by the VOC P.1 as the most prevalent lineage in Uruguay since April 2021, the concurrent emergence of Spike mutations Q675H and Q677H in VOIs and/or VOCs circulating worldwide should be closely monitored.
Discussion: An ancestral B.1.1.28 virus carrying mutation Q675H was probably introduced from southeastern Brazil into Montevideo, Uruguay's capital city, and by November 2020 the virus already fixed mutation Q677H and spread across the entire country, originating lineage P.6.
Discussion: Convergent evolution is a hallmark of positive selection, and we identified the independent appearance of both S:Q675H and S:Q677H in
Evaluation of the clinical and analytical performance of the Seegene allplex SARS-CoV-2 variants I assay for the detection of variants of concern (VOC) and variants of interests (VOI).
SARS_CoV_2 mutation literature information.
PMID: 
2022
Infection, genetics and evolution
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