literature

SARS_CoV_2 mutation literature information.

SARS-CoV-2 Delta (B.1.617.2) Variant: A Unique T478K Mutation in Receptor Binding Motif (RBM) of Spike Gene.

PMID: 34796036 2021 Immune network

Table: Q677H

Dynamics prediction of emerging notable spike protein mutations in SARS-CoV-2 implies a need for updated vaccines.

PMID: 34508827 2021 Biochimie

Table: Q677H

Figure: * The codes on the x and y axes of the matrix include: s001A: 20A, s002A: 19A, s003A: 20A/S.A262S, s004A: 20A/S.A701V, s005A: 20A/S.D80A, s006A: 20A/S.E484K, s007A: 20A/S.E484Q, s008A: 20A/S.K417 N, s009A: 20A/S.L452R, s010A: 20A/S.N501T, s011A: 20A/S.N501Y, s012A: 20A/S.P681H, s013A: 20A/S.P681R, s014A: 20A/S.Q675H, s015A: 20A/S.Q675P, s016A: 20A/S.Q677H, s017A: 20A/S.Q677P, s018A: 20A/S.V1176F, s019A: 20A/S.

Mutation-Induced Long-Range Allosteric Interactions in the Spike Protein Determine the Infectivity of SARS-CoV-2 Emerging Variants.

PMID: 34805715 2021 ACS omega

Table: Q677H

Additional Positive Electric Residues in the Crucial Spike Glycoprotein S Regions of the New SARS-CoV-2 Variants.

PMID: 34880635 2021 Infection and drug resistance

Table: Q677H

Importation, circulation, and emergence of variants of SARS-CoV-2 in the South Indian state of Karnataka.

PMID: 35243004 2021 Wellcome open research

Discussion: Four viruses in our study have mutations resulting in amino acid changes at this position (Q677H (n=3), Q677P (n=1)) (extended data, S6 ).

The Development of SARS-CoV-2 Variants: The Gene Makes the Disease.

PMID: 34940505 2021 Journal of developmental biology

Introduction: In some strains, it bears Q677H, whereas in others it is Q677P.

SARS-CoV-2 Delta Variant Displays Moderate Resistance to Neutralizing Antibodies and Spike Protein Properties of Higher Soluble ACE2 Sensitivity, Enhanced Cleavage and Fusogenic Activity.

PMID: 34960755 2021 Viruses

Result: Furthermore, continued surveillance is necessary as several independent lineages have recently emerged containing additional substitutions proximal to S1/S2 cleavage junction, such as the B.1.2 and B.1.525 with Q677H, C.37 and B.1.617.2 with Q675H, and C.1.2 with N679K substitutions.

Role of Q675H Mutation in Improving SARS-CoV-2 Spike Interaction with the Furin Binding Pocket.

PMID: 34960779 2021 Viruses

Discussion: This variant carries a series of mutations in SARS-CoV-2 genome, among which the spike substitution Q677H, highlighting the crucial role of histidine in the release of SARS-CoV-2 S1 and S2 units operated by furin.

Molecular Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Isolates From Central Inner Sardinia.

PMID: 35095827 2021 Frontiers in microbiology

Table: p.Gln677His

Phylodynamic Pattern of Genetic Clusters, Paradigm Shift on Spatio-Temporal Distribution of Clades, and Impact of Spike Glycoprotein Mutations of SARS-CoV-2 Isolates from India.

PMID: 35017872 2021 Journal of global infectious diseases

Result: Figure 4 shows prevalent mutations such as D614G, Q677H and P681H originated during March, April and July respectively and their appearance was observed till the end of the year 2020.

Figure: D614G, Q677H and P681H mutations originated during the first half of the year and their appearance was observed throughout the year; L54F, K77M and P812 L mutations emerged during the first half of the year but absent after few months of their appearance.

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