literature

SARS_CoV_2 mutation literature information.

Multiple SARS-CoV-2 Variants Exhibit Variable Target Cell Infectivity and Ability to Evade Antibody Neutralization.

PMID: 35371108 2022 Frontiers in immunology

Discussion: The P681H, P681R, and Q677H mutation sites in the variants are located near the furin cleavage site, which may affect the cleavage of S protein.

Longitudinal analysis of SARS-CoV-2 spike and RNA-dependent RNA polymerase protein sequences reveals the emergence and geographic distribution of diverse mutations.

PMID: 34801754 2022 Infection, genetics and evolution

Result: Q677H has been observed in the United States in October 2020 by Hodcroft et al.

Result: Q677H, observed in 2146 sequences (0.62% of total sequences), occurs outside of the furin cleavage site but may affect a QTQN consensus sequence near the site.

Result: S17) reveals 14 mutations out of 64 total that appear to be consistently present (P681H, Q677H, Q675H, Q677P, S673T, N679K, P681R, Q675R, P681L, T676I, T678I, A684V, Q677R, and

Occurrence of a substitution or deletion of SARS-CoV-2 spike amino acid 677 in various lineages in Marseille, France.

PMID: 34839413 2022 Virus genes

Result: Also, eight genomes were classified in the Marseille-501/A.27 lineage that was first detected in our institute in January 2021, accounted for 18 genomes in our database and which may or may not harbour Q677H substitution.

Result: Codon changes from CAG to CAT or CAC leading to this Q677H substitution deoptimise the viral codon usage relative to that of the human genome.

Result: Finally, viral neutralisation in the presence of a monoclonal conformation-dependent antibody targeting the spike receptor binding domain led to a 50% reduction in neutralisation of 677H-harbouring spike relative to 677Q-harbouring spike (wild type), and of Q677H/D614G-harbouring spike

Haplotype distribution of SARS-CoV-2 variants in low and high vaccination rate countries during ongoing global COVID-19 pandemic in early 2021.

PMID: 34848355 2022 Infection, genetics and evolution

Table: Q677H

A comprehensive overview of identified mutations in SARS CoV-2 spike glycoprotein among Iranian patients.

PMID: 34896524 2022 Gene

Table: Q677H

Efficacy of mRNA, adenoviral vector, and perfusion protein COVID-19 vaccines.

PMID: 34906769 2022 Biomedicine & pharmacotherapy

Table: Q677H

Comparative mutational analysis of SARS-CoV-2 isolates from Pakistan and structural-functional implications using computational modelling and simulation approaches.

PMID: 34968862 2022 Computers in biology and medicine

Result: As a result, the D614G, Q677H double mutant enhanced binding efficiency, and this mutant, as well as other interface residues, are important hotspots for therapeutic development against SARS-CoV-2 variants.

Result: As given in Table 5 , the total binding energy for the D614G-Q677H variant was -75.78 kcal/mol followed by the D614G-S943T-V622F variant -75.17 kcal/mol and -73.84 kcal/mol for the N74K-D614G variant.

Result: Moreover, the strength of the wild type and mutants was ranked as D614G-Q677H variant (1.0 E-09), wild type (1.9 E-09) while for the N74K-<

Emergence of two distinct variants of SARS-CoV-2 and an explosive second wave of COVID-19: the experience of a tertiary care hospital in Pune, India.

PMID: 35000004 2022 Archives of virology

Result: Two isolates, CD210922 (MW969752) and CD210896 (EPI_ISL_1710598), had the unique mutations V143F, Q677H, and N440K (Table 2).

Functional analysis of polymorphisms at the S1/S2 site of SARS-CoV-2 spike protein.

PMID: 35333910 2022 PloS one

Result: Mutants Q675R, Q677H, P681H, P681L, A684S, A684T, A684V and V687L facilitated entry into all cell lines tested with comparable or up to two-fold enhanced/decreased efficiency compared to WT SARS-CoV-2 S (Fig 4A).

Result: The remaining mutations under study include Q675R, Q677H, S686G, V687L and A688V (Fig 1B).

Evolutionary dynamics of SARS-CoV-2 circulating in Yogyakarta and Central Java, Indonesia: sequence analysis covering furin cleavage site (FCS) region of the spike protein.

PMID: 35165816 2022 International microbiology

Result: Two sequences (3.85%) came from Yogyakarta containing Q677H mutation as of August 2020.

Result: We detected several mutations accompanying the D614G variant, i.e., Q675H, Q677H, S680P, and silent mutation in 23,557 C > T.

Figure: Analysis of the maximum clade credibility (MCC) tree in the research samples and the Indonesian samples obtained from GISAID data showed the formation of five clusters from the FCS region, with S680P and Q677H in the same cluster.

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