literature

Evolutionary dynamics of SARS-CoV-2 circulating in Yogyakarta and Central Java, Indonesia: sequence analysis covering furin cleavage site (FCS) region of the spike protein.

PMID: 35165816 2022 International microbiology

Abstract: Several mutations were identified in the FCS region, i.e., D614G, Q675H, Q677H, S680P, and silent mutation in 235.57 C > T.

Result: Other variants S680P and Q675H were observed from Central Java with 1.92% of each in June and October 2020, respectively.

Result: We detected several mutations accompanying the D614G variant, i.e., Q675H, Q677H, S680P, and silent mutation in 23,557 C > T.

Analysis of SARS-COV2 spike protein variants among Iraqi isolates.

PMID: 34754982 2022 Gene reports

Abstract: Twenty-two distinct mutations were identified within the spike protein regions which were: L5F, L18F, T19R, S151T, G181A, A222V, A348S, L452 (Q or M), T478K, N501Y, A520S, A522V, A570D, S605A, D614G, Q675H, N679K, P681H, T716I, S982A, A1020S,

PMID: 34801754 2022 Infection, genetics and evolution

Result: S17) reveals 14 mutations out of 64 total that appear to be consistently present (P681H, Q677H, Q675H, Q677P, S673T, N679K, P681R, Q675R, P681L, T676I, T678I, A684V, Q677R, and A672V).

A comprehensive overview of identified mutations in SARS CoV-2 spike glycoprotein among Iranian patients.

PMID: 34896524 2022 Gene

Table: Q675H

Emergence of a novel SARS-CoV-2 Pango lineage B.1.1.526 in West Bengal, India.

PMID: 34896696 2022 Journal of infection and public health

Table: Q675H

Emergence of two distinct variants of SARS-CoV-2 and an explosive second wave of COVID-19: the experience of a tertiary care hospital in Pune, India.

PMID: 35000004 2022 Archives of virology

Result: Two sequences from 2021 (CD211295 [MW969753] and CD210761 [MZ021503]) belonging to the original prevalent lineage B.1.1.306 had four characteristic mutations, L18F, A27S, E484K, and Q675H, in the spike protein.

Evaluation of the clinical and analytical performance of the Seegene allplex SARS-CoV-2 variants I assay for the detection of variants of concern (VOC) and variants of interests (VOI).

PMID: 34628158 2021 Journal of clinical virology

Table: Q675H

Phylodynamic Pattern of Genetic Clusters, Paradigm Shift on Spatio-Temporal Distribution of Clades, and Impact of Spike Glycoprotein Mutations of SARS-CoV-2 Isolates from India.

PMID: 35017872 2021 Journal of global infectious diseases

Discussion: In contrast, the report suggested that mutations such as L54F, G431S, E471D, G502R, Q506H, P507S, Y508N, E583D and Q675H could weaken the interaction of S-protein with ACE2 receptor; whereas, N440K, E471Q and G504V could improve the binding affinity.

Discussion: Though D614G is associated with increased infectivity, mutations such as Q239R, T719I, T719S, D8

Emergence and Spread of a B.1.1.28-Derived P.6 Lineage with Q675H and Q677H Spike Mutations in Uruguay.

PMID: 34578382 2021 Viruses

Discussion: Notably, another study that developed an innovative model on epidemiological variables integrating the effect of Spike amino acid changes in viral fitness forecasted that mutations Q675H and Q677H could appear in emerging SARS-CoV-2 VOCs in the following months.

Discussion: We are not aware of any experimental assay that assessed the effect of mutations S:Q675H + Q677H on

Discussion: We propose that simultaneous presence of Spike mutations Q675H and Q677H might confer to lineage P.6 a higher infectivity and increased transmissibility, which, combined with the establishment in the populated metropolitan region, contributed to its swift dissemination in Uruguay.

Dynamics prediction of emerging notable spike protein mutations in SARS-CoV-2 implies a need for updated vaccines.

PMID: 34508827 2021 Biochimie

Method: The chosen sequences of single mutations included the following amino acid substitutions: L5F, L18F, D80A, S98F, A222V, A262S, P272L, K417 N, N439K, L452R, Y453F, S477 N, E484K, E484Q, N501T, N501Y, E583D, D614G, Q675H, Q675P, Q677H,

Filtrator