Spike protein cleavage-activation mediated by the SARS-CoV-2 P681R mutation: a case-study from its first appearance in variant of interest (VOI) A.23.1 identified in Uganda.
Abstract: The A.23 viral lineage, characterized by three spike mutations F157L, V367F and Q613H, was first identified in COVID-19 cases from a Ugandan prison in July 2020, and then was identified in the general population with additional spike mutations (R102I, L141F, E484K and P681R) to comprise lineage A.23.1 by September 2020, with this virus being designated a variant of interest (VOI) in Africa and with subsequent spread to 26 other countries.
Introduction: Both lineages have undergone significant diversification as they expanded; with this expansion apparently linked to a key S gene mutation
A year living with SARS-CoV-2: an epidemiological overview of viral lineage circulation by whole-genome sequencing in Barcelona city (Catalonia, Spain).
Discussion: Apart from the lineage-defining changes in variants Delta-like, additional substitutions were observed such as T95I, P251L in the N-terminal domain, Q613H and T719I during the following weeks (data not shown).
Travel ban effects on SARS-CoV-2 transmission lineages in the UAE as inferred by genomic epidemiology.
Result: We discovered one case of Q613H, directly adjacent to position 614 in S, almost unique to the UAE.
Novel SARS-CoV-2 variants: the pandemics within the pandemic.
PMID: 34015535
2021
Clinical microbiology and infection
Method: A.23.1, is notable for its lack of the D614G mutation, with a Q613H mutation instead that may be functionally similar.
Bioinformatics Analysis Unveils Certain Mutations Implicated in Spike Structure Damage and Ligand-Binding Site of Severe Acute Respiratory Syndrome Coronavirus 2.
PMID: 34121839
2021
Bioinformatics and biology insights
Table: Q613H
Updated SARS-CoV-2 single nucleotide variants and mortality association.
Discussion: We further identified 41 and 30 SNVs with at least twofold higher occurrence rates in the death and nondeath group, respectively, including several mutations on the S protein, for example, G25088T (S:V1176F), G23401T (S:Q613H), G24197T (S:A879S), and T24811A (S:1083Q).
Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.
Introduction: PANGO reports, which are available online, currently include five linages; B.1.1.7 or known as UK linage (N501Y, P681H and other mutations), B.1.351 or known as South Africa linage (501Y.v2), P.1 or known as Brazil linage (E484K, N501Y and K417T), A.23.1 linage (F157L, V367F, Q613H and P681R) and B.1.525 linage (E484K, Q677H, F888L).
SARS_CoV_2 mutation literature information.
PMID: 
2022
bioRxiv
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