literature

SARS_CoV_2 mutation literature information.

Mutational landscape of SARS-CoV-2 genome in Turkey and impact of mutations on spike protein structure.

PMID: 34871297 2021 PloS one

Table: Gln57His

SARS-CoV-2 genetic variations associated with COVID-19 pathogenicity.

PMID: 34870573 2021 Microbial genomics

Table: Q57H

Genome-wide characterization of SARS-CoV-2 cytopathogenic proteins in the search of antiviral targets.

PMID: 34845452 2021 bioRxiv

Abstract: To further characterize the mechanism, we tested a natural ORF3a Beta variant, Q57H, and a mutant with deletion of the highly conserved residue, DeltaG188.

Method: The ORF3a mutant variants (Q57H and DeltaG188) were generated by overlapping PCR with mutant-specific primers (Table S1) and cloned onto the same pLVX-EF1alpha-IRES-Puro plasmid via Gibson assembly method.

Discussion: For example, the Q57H mutant was predicted to bind S protein, whereas the wildtype does not.

A next generation sequencing (NGS) analysis to reveal genomic and proteomic mutation landscapes of SARS-CoV-2 in South Asia.

PMID: 34841355 2021 Current research in microbial sciences

Result: According to the H-clades (Q57H), 71 South Asian samples (13.71%) were clustered where the samples of India (44) were found as the most dominant one.

Table: Q57H

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a Dog in Connecticut in February 2021.

PMID: 34834948 2021 Viruses

Result: We found amino acid substitutions in Spike (D614G), N (D377Y, P67S, P199L), NS3 (G172V, Q57H), NS8 (S24L) NSP2 (T85I), NSP4 (M458I), NSP5 (L89F), NSP12 (P323L), NSP14 (N129D), and NSP16 (R216C) proteins.

Genome-wide identification and prediction of SARS-CoV-2 mutations show an abundance of variants: Integrated study of bioinformatics and deep neural learning.

PMID: 34812411 2021 Informatics in medicine unlocked

Result: Mutations [L5F, and R80I], S97I, and [L46C, V48G, G49I, Q57H, W131R, G172V, Q185H, and Y206S] were identified to have a deleterious effect on ORF7a, ORF8, and ORF3a proteins, respectively.

Result: Out of 46, 25 missense mutations (D1118H, S194L, R262H, M809L, P314L, A8D,

PMID: 34767598 2021 PLoS pathogens

Result: One of the two mink from farm A had mutations at T85I-NSP2, S1205L-NSP3, G37E-NSP9, P323L-NSP12, T91M-NSP15, D614G-spike, N501T-spike, Q57H- Discussion: The NS3_Q57H mutation is common in the USA and is predicted to be deleterious.

Discussion: The G clade was subsequently divided into GR clade containing N_203-204: RG>KR and GH clade with NS3_Q57H aa substitutions.

Host Response to SARS-CoV2 and Emerging Variants in Pre-Existing Liver and Gastrointestinal Diseases.

PMID: 34760721 2021 Frontiers in cellular and infection microbiology

Introduction: Further, L clade evolved to V (G11083T, G26144T, NSP6-L37F + NS3-G251V) and G (C241T, C3037T, A23403G, and S-D614G); and later G clade evolved into GH (C241T, C3037T, A23403G, G25563T includes S-D614G + NS3-Q57H), GR (C241T, C3037T,

Clinico-Genomic Analysis Reveals Mutations Associated with COVID-19 Disease Severity: Possible Modulation by RNA Structure.

PMID: 34578142 2021 Pathogens (Basel, Switzerland)

Result: The Q57H mutation of ORF3a was seen in more than 50% of the isolates (Table 2).

Characterization of SARS-CoV-2 East Java isolate, Indonesia.

PMID: 34621509 2021 F1000Research

Table: Q57H