literature

SARS_CoV_2 mutation literature information.

Genomic Epidemiology of SARS-CoV-2 Infection During the Initial Pandemic Wave and Association With Disease Severity.

PMID: 33900399 2021 JAMA network open

Discussion: Similar to our findings, prevalent variants include 23403A>G (D614G Spike), 14408C>T (P323L ORF1ab), and 25563G>T (Q57H ORF3a).

Impact of meteorological parameters and population density on variants of SARS-CoV-2 and outcome of COVID-19 pandemic in Japan.

PMID: 33908339 2021 Epidemiology and infection

Result: Among 22 point mutations at N and other eight non-structural proteins, eight namely, N_S194L, N_R203K, N_G204R, NS3_Q57H, NSP2_T85I, NSP5_G15S, NSP6_L37F and NSP12_P323L were persistent throughout the COVID-19 pandemic in Japan.

Table: Q57H

Genetic Diversity of SARS-CoV-2 over a One-Year Period of the COVID-19 Pandemic: A Global Perspective.

PMID: 33920487 2021 Biomedicines

Result:

Result: (iv) Temporal trends of the NSP2 variant T85I (Figure 5D) and the ORF3a variant Q57H were distinct on different continents.

Discussion: Additionally, other variants like S25L in NSP7, S194L, R203K, G204R, and T205I in nucleocapsid, T85I and I120F in NSP2, S477N in spike, and Q57H in ORF3a have also been confirmed by previous studies.

Mutation Signatures and In Silico Docking of Novel SARS-CoV-2 Variants of Concern.

PMID: 33925854 2021 Microorganisms

Result: In addition, the SA-VOC has several aa substitutions in NSP2 (R4C), NSP3 (K837N), NSP12 (P323L), NSP13 (E168D), NSP14 (S28C), and NSP15 (P205L), NS3 (Q57H, S171L), E (P71L), N-protein (T205I) (Table 1).

Result: The COH-VOC has two mutations at positions N501Y and D614G in the S-

SARS-CoV-2 mutations: the biological trackway towards viral fitness.

PMID: 33928885 2021 Epidemiology and infection

Introduction: Among 51 non-synonymous mutations in ORF3a, Q57H (17.4%) and G251V (9.7%) were predominant ones of which Q57H mutation was found to cause disease severity in hospitalised.

Introduction: Among the accessory proteins, ORF3a and ORF8 are brought into limelight due to the rapid spread of cluster V (NSP3:F106F, RdRp:P323L, S:D614G and ORF3a:Q57H) and VI (NSP4:S76S and ORF8

Genome sequencing of SARS-CoV-2 in a cohort of Egyptian patients revealed mutation hotspots that are related to clinical outcomes.

PMID: 33932525 2021 Biochimica et biophysica acta. Molecular basis of disease

Result: Additionally, 21 missense mutations in ORF3a were identified, resulting in APA-viroporin Q57H variants.

D936Y and Other Mutations in the Fusion Core of the SARS-CoV-2 Spike Protein Heptad Repeat 1: Frequency, Geographical Distribution, and Structural Effect.

PMID: 33946306 2021 Molecules (Basel, Switzerland)

Result: In addition, the GH clade presents the NS3-Q57H mutation, the GR clade presents the N-G204R mutations, and GV clade presents the S-A222V mutation.

Tracing genetic signatures of bat-to-human coronaviruses and early transmission of North American SARS-CoV-2.

PMID: 33966351 2021 Transboundary and emerging diseases

Result: Thr265 Ile and Gln57 His) in ORF1ab and ORF3a, respectively.

Table: Gln57His

SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes.

PMID: 33976134 2021 Nature communications

Result: For example, the B.1.1.7 lineage includes mutations C5388A (orf1ab:A1708D) in a string of 7 perfectly conserved amino acids in a well-conserved region of nsp3, C14676T, a synonymous change in a large SCE in RdRp (situated between two conserved structures predicted by RNAz so possibly part of a containing structure too large for the prediction algorithm), T24506G (spike:S982A) in an extremely well-conserved region of S2, a three-nucleotide mutation at position 28280 (nucleocapsid:D3L) which weakens the initiation context of ORF9b, and C27972T (

Identification of E484K and other novel SARS-COV-2 variants from the Kingdom of Bahrain.

PMID: 34058304 2021 Microbial pathogenesis

Table: Q57H,N

Table: Q57H

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