Discussion: Many other missense and synonymous mutations found in respective proteins of Bangladeshi virus populations such as ORF1ab/nsp12_P323L, NS3_Q57H, NS8_R52I, N_S194L, N_R203K, and N_G204R, which are also common worldwide.
An Epidemiological Analysis of SARS-CoV-2 Genomic Sequences from Different Regions of India.
Result: Firstly, the GR-GH variants defined by the presence of the D614G, G204R, and Q57H mutations in the S, N, and ORF3a proteins, respectively, were observed in 14 sequences from different parts of India, starting from May 2020 (Figure 2).
The Spike of Concern-The Novel Variants of SARS-CoV-2.
Introduction: Clade GR (D614G + G204R in the nucleocapsid (N) protein; reference sequence: EPI_ISL_850687) is currently dominating Africa (41.1%), Asia (52.7%), Oceania (74.8%), and South America (66.8%), while GH (D614G + Q57H in the NS3 protein; reference sequence: EPI_ISL_861025) reigns in North America (59.0%).
Molecular epidemiology of SARS-CoV-2 isolated from COVID-19 family clusters.
Result: Second amino acid mutations that were frequently detected were P232L substitution on NSP12 (RdRp) protein (15x), followed by Q57H substitution on NS3 (14x) and P822L substitution on NSP3 protein (13x).
Table: Q57H
High Prevalence of SARS-CoV-2 Genetic Variation and D614G Mutation in Pediatric Patients With COVID-19.
PMID: 34095334
2021
Open forum infectious diseases
Discussion: G25563T leads to the Q57H missense mutation ORF3a that is associated with host cell apoptosis and contributes to increased infectivity and virulence.
Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review.
PMID: 34103090
2021
European journal of medical research
Table: Q57H
Global variation in SARS-CoV-2 proteome and its implication in pre-lockdown emergence and dissemination of 5 dominant SARS-CoV-2 clades.
PMID: 34147651
2021
Infection, genetics and evolution
Figure: B-H) Global distribution of (represented by percentage frequency) highly recurring mutations: B) Nsp2:T85I, C) Nsp6:L37F, D) Nsp12:P323L, E) Spike:D614G, F) ORF3a:Q57H, G) N protein:R203K and H) N protein:G204R.
Discussion: For instance, Nsp2:T85I and ORF3a:Q57H (mostly occur together) along with Spike:
Development of a genotyping platform for SARS-CoV-2 variants using high-resolution melting analysis.
PMID: 34154921
2021
Journal of infection and chemotherapy
Table: Q57H
Multilevel systems biology analysis of lung transcriptomics data identifies key miRNAs and potential miRNA target genes for SARS-CoV-2 infection.
PMID: 34157472
2021
Computers in biology and medicine
Table: Q57H
Activation of NF-kappaB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2.
Introduction: According to additional mutation, the clade G can be split into three subclades, clade GH (Q57H variant of ORF3a), clade GR (RG203KR variant of the nucleocapsid protein), and GV (A222V variant of the spike protein).
SARS_CoV_2 mutation literature information.
PMID: 
2021
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