Result: The B.1.351 VOC was characterized by K417N, E484K, N501Y in the spike region and 19 mutations and 2 deletions as follows: ORF1ab: T265I, R724K, S1612L, K1655N, K3353R, SGF 3675_F3677del, P4715L, E5585D; spike: D80A, D215G, L242_L244del, A262D, D614G, C1247F; ORF3a: Q57H, PMID: 34258267
2021
BioMed research international
Abstract: Four hotspot mutations were found in all geographical locations at least once: T265I (NSP2), P314L (NSP12), D614G (S), and Q57H (ORF3a).
Coding-Complete Genome Sequences of 11 SARS-CoV-2 B.1.1.7 and B.1.351 Variants from Metro Manila, Philippines.
Abstract: In addition, a retention of Q57H (B.1.X), R203K/G204R (B.1.1.X), T85I (B.1.2-B.1.3), G15S+T428I (C.X), and I120F (D.X) variations was observed.
Result: Other major mutations noted are Q57H (26.5%),
Table: Q57H
Discussion: In addition, we also observed a positive natural selection of Q57H (B.1.X), R203K/G204R (B.1.1.X), T85I (B.1.2-B.1.3), G15S+T428I (C.X), and I120F (D.X) variants.
Ongoing global and regional adaptive evolution of SARS-CoV-2.
Correlates of SARS-CoV-2 Variants on Deaths, Case Incidence and Case Fatality Ratio among the Continents for the Period of 1 December 2020 to 15 March 2021.
Result: The NS3_Q57H mutation was reported at 46.10%, 32.99% and 63.30% in SARS-CoV-2 genome sequences isolated from Africa, Australia and North America, respectively.
Emergence and expansion of SARS-CoV-2 B.1.526 after identification in New York.
Introduction: Non-spike mutations widely shared by B.1.526-E484K and B.1.526-S477N isolates include: T85I in ORF1a-nsp2; L438P in ORF1a-nsp4, a 9-base pair (bp) deletion (Delta106-108) in ORF1a-nsp6; P323L in ORF1b-nsp12; Q88H in ORF1b-nsp13; Q57H in ORF3a; and P199L and M234I in the N<
Molecular Epidemiology of SARS-CoV-2 in Diverse Environmental Samples Globally.