literature

SARS_CoV_2 mutation literature information.

Novel Nested-Seq Approach for SARS-CoV-2 Real-Time Epidemiology and In-Depth Mutational Profiling in Wastewater.

PMID: 34445204 2021 International journal of molecular sciences

Result: Five well-characterized missense mutations, D614G (23403A>G)-S gene, Q57H (25563G>T)-ORF3a gene, P323L (14408C>T):ORF1ab/RdRP gene, R203K (28881G>A):N gene, and G204R (28883G>C):N gene, were initially targeted as proof-of-principle of our methodology to perform the analysis and quantification of SARS-CoV-2 mutations/strains in wastewater samples.

Result: Interestingly, the

PMID: 34452390 2021 Viruses

Discussion: This included T85I in the nsp2 gene, P423L in the nsp12 gene, D614G in the S gene, and Q57H in the ORF3a gene.

Molecular characterization of SARS-CoV-2 from Bangladesh: implications in genetic diversity, possible origin of the virus, and functional significance of the mutations.

PMID: 34458642 2021 Heliyon

Table: Q57H

Discussion: One study mentioned that the Q57H mutation in ORF3a protein may decrease ion permeability by creating a tighter constriction in channel pore and possibly decrease viral release and immune response (Ul Alam et al.).

Discussion: Our analysis suggested the Q57H decreases protein stability with altered protein function may result in loss of a CD4+ T Cell epitope similar to other studies.

Higher entropy observed in SARS-CoV-2 genomes from the first COVID-19 wave in Pakistan.

PMID: 34464419 2021 PloS one

Result: The most frequent variants were observed at positions 5' UTR; 241C>T (78.8%), S gene D614G (76%) Orf1ab; Nsp3 924F (74%), Orf1ab; RdRp P4715L (72%), Orf3a&nbs

Discussion: The most common non-synonymous variants observed were S D614G, Orf1ab RdRp gene P4715L and, Orf3a Q57H which have previously been reported from Europe and the United States.

Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants.

PMID: 34465019 2021 mBio

Table: Q57H

Bioinformatic analysis of the whole genome sequences of SARS-CoV-2 from Indonesia.

PMID: 34540148 2021 Iranian journal of microbiology

Table: Q57H

Characterisation of SARS-CoV-2 clades based on signature SNPs unveils continuous evolution.

PMID: 34547443 2021 Methods (San Diego, Calif.)

Abstract: Such changes which are common for both global dataset without Indian and dataset of exclusive Indian sequences are R203M in Nucleocapsid for 20B, T85I and Q57H in NSP2 and ORF3a respectively for 20C while for exclusive Indian sequences such unique changes are A97V in RdRp, G339S and G339C in NSP2 in 19A and Q57H in ORF3a in 20A.

Genomic analysis of early transmissibility assessment of the D614G mutant strain of SARS-CoV-2 in travelers returning to Taiwan from the United States of America.

PMID: 34557346 2021 PeerJ

Result: In addition to the S-protein D614G mutation, other missense mutations were identified in NSP12 (RNA dependent RNA polymerase; RdRp) with a P323L mutation, a T85I mutation in NSP2, and a Q57H mutation in ORF3a protein.

Table: Q57H

Clinico-Genomic Analysis Reveals Mutations Associated with COVID-19 Disease Severity: Possible Modulation by RNA Structure.

PMID: 34578142 2021 Pathogens (Basel, Switzerland)

Result: The Q57H mutation of ORF3a was seen in more than 50% of the isolates (Table 2).

Assessment of intercontinents mutation hotspots and conserved domains within SARS-CoV-2 genome.

PMID: 34606987 2021 Infection, genetics and evolution

Result: In addition, very high rate recurrent mutations exist at the following locations: spike protein; D614G, nucleocapsid phosphoprotein; S194L, R203K and G204R, ORF3a; Q57H and G251V, and ORF8; L84S.

Result: The 78% viral samples bearing the D614G and P4715L mutations also bears either the concurrent N protein R203K and G204R or the ORF3a Q57H muta

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