Abstract: Sentinel GH-clade ORF3a:p.Q57H variants constricted the ion-channel through intertransmembrane-domain interaction of cysteine(C81)-histidine(H57).
Introduction: Although the possible role of Result: Q57H substitution in ORF3a viroporin: The roles of decreased ion permeability.
Result: Conversely, we have not found any literature for even other coronaviruses that showed ORF3a: p.Q57H correlating with the rest of the co-occurring mutations.
Table: Q57H
Figure: The effect on transmembrane channel pore of ORF3a viroporin due to p.Q57H mutation.
High-Throughput Next-Generation Sequencing Respiratory Viral Panel: A Diagnostic and Epidemiologic Tool for SARS-CoV-2 and Other Viruses.
Abstract: The clade for pangolin lineage B that contains certain distant variants, including P4715L in ORF1ab, Q57H in ORF3a, and S84L in ORF8 covarying with the D614G spike protein mutation, were the most prevalent early in the pandemic in Georgia, USA.
Result: Through our Nextstrain thread, it was observed that the clade for pangolin lineage B contains certain distant variants, including P4715L in ORF1ab, Q57H in ORF 3a, and S84L in ORF8 covarying with the D614G
Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using in Silico Approach.
Result: Other than the S protein, the majority of beta (B.1.351) genomes had amino acid changes within ORF1a (T265I, K1655N, K3353R), ORF1b (P214L), ORF3a (Q57H, S171L), E (P71L), and N (T205I).
Genomic surveillance reveals the detection of SARS-CoV-2 delta, beta, and gamma VOCs during the third wave in Pakistan.
Result: D614G increased from 74.6% to 99.9%; T265I, Q57H, R203K, and G204R started to increase in March and gradually decreased in July (Figure 3D).
Table: Q57H
Discussion: A previous study reported that the Q57H variant could cause dramatic changes in protein structures and decrease the flexibility of domains, thereby enhancing the binding affinities in ORF3a-M and ORF3a-S complexes.
Discussion: For example, the Q57H variant, which was found to occur in the ORF3a protein, had a higher frequency in severe cases (39.36%) than in asymptomatic cases (10
Analysis of 329,942 SARS-CoV-2 records retrieved from GISAID database.
PMID: 34735950
2021
Computers in biology and medicine
Discussion: T85I is noted to co-occur with Q57H, and P504L - with Y541C.
Discussion: Interestingly, Q57H and R203K were found to cause substantial changes in protein structures (RMSD >=5.0 A).
Discussion: The ORF3a gene had a G25563T (Q57H) mutation, found in 21.41% of the genomes.
Discussion: After March 2020, the D614G clade became increasingly prevalent worldwide, expanding from 22 to 42 countries with GH (D614G + Q57H in the NS3) dominant in North America (59.0%).
Host Response to SARS-CoV2 and Emerging Variants in Pre-Existing Liver and Gastrointestinal Diseases.
PMID: 34760721
2021
Frontiers in cellular and infection microbiology
Introduction: Further, L clade evolved to V (G11083T, G26144T, NSP6-L37F + NS3-G251V) and G (C241T, C3037T, A23403G, and S-D614G); and later G clade evolved into GH (C241T, C3037T, A23403G, G25563T includes S-D614G + NS3-Q57H), GR (C241T, C3037T,
An outbreak of SARS-CoV-2 with high mortality in mink (Neovison vison) on multiple Utah farms.
Result: One of the two mink from farm A had mutations at T85I-NSP2, S1205L-NSP3, G37E-NSP9, P323L-NSP12, T91M-NSP15, D614G-spike, N501T-spike, Q57H- Discussion: The NS3_Q57H mutation is common in the USA and is predicted to be deleterious.
Discussion: The G clade was subsequently divided into GR clade containing N_203-204: RG>KR and GH clade with NS3_Q57H aa substitutions.
SARS_CoV_2 mutation literature information.
PMID: 
2021
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