literature

SARS_CoV_2 mutation literature information.

Multiorgan and Vascular Tropism of SARS-CoV-2.

PMID: 35336922 2022 Viruses

Result: Various mutations were present in the stomach lining biopsy, especially the Q57H (ORF3a), reaching 98.6%, but were not detected in other tissues.

SARS-CoV-2 Mutations and Their Impact on Diagnostics, Therapeutics and Vaccines.

PMID: 35273977 2022 Frontiers in medicine

Introduction: In the US, Q57H mutation in the ORF3a region, and S24L and L84S in ORF8 was found to be prevalent, suggesting a positive effect on transmission or virulence.

Table: Q57H

Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants.

PMID: 34465019 2021 mBio

Table: Q57H

Ongoing global and regional adaptive evolution of SARS-CoV-2.

PMID: 34292871 2021 Proc Natl Acad Sci U S A

Result: Q57H is the fourth most common positively selected mutation.

Result: In addition to the many mutations of interest in the N and S proteins, Orf3a Q57H is a signature mutation for partitions 6, 7, and v1.

Near-Complete Genome Sequences of Nine SARS-CoV-2 Strains Harboring the D614G Mutation in Malaysia.

PMID: 34351228 2021 Microbiology resource announcements

Table: Q57H

Correlates of SARS-CoV-2 Variants on Deaths, Case Incidence and Case Fatality Ratio among the Continents for the Period of 1 December 2020 to 15 March 2021.

PMID: 34356077 2021 Genes

Result: The NS3_Q57H mutation was reported at 46.10%, 32.99% and 63.30% in SARS-CoV-2 genome sequences isolated from Africa, Australia and North America, respectively.

Molecular characterization of SARS-CoV-2 from Bangladesh: implications in genetic diversity, possible origin of the virus, and functional significance of the mutations.

PMID: 34458642 2021 Heliyon

Table: Q57H

Discussion: One study mentioned that the Q57H mutation in ORF3a protein may decrease ion permeability by creating a tighter constriction in channel pore and possibly decrease viral release and immune response (Ul Alam et al.).

Discussion: Our analysis suggested the Q57H decreases protein stability with altered protein function may result in loss of a CD4+ T Cell epitope similar to other studies.

Molecular epidemiology of SARS-CoV-2 isolated from COVID-19 family clusters.

PMID: 34074255 2021 BMC medical genomics

Result: Second amino acid mutations that were frequently detected were P232L substitution on NSP12 (RdRp) protein (15x), followed by Q57H substitution on NS3 (14x) and P822L substitution on NSP3 protein (13x).

Table: Q57H

The Algerian Chapter of SARS-CoV-2 Pandemic: An Evolutionary, Genetic, and Epidemiological Prospect.

PMID: 34452390 2021 Viruses

Discussion: This included T85I in the nsp2 gene, P423L in the nsp12 gene, D614G in the S gene, and Q57H in the ORF3a gene.

Higher entropy observed in SARS-CoV-2 genomes from the first COVID-19 wave in Pakistan.

PMID: 34464419 2021 PloS one

Result: The most frequent variants were observed at positions 5' UTR; 241C>T (78.8%), S gene D614G (76%) Orf1ab; Nsp3 924F (74%), Orf1ab; RdRp P4715L (72%), Orf3a&nbs

Discussion: The most common non-synonymous variants observed were S D614G, Orf1ab RdRp gene P4715L and, Orf3a Q57H which have previously been reported from Europe and the United States.

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