Discussion: While the earliest samples from the United Stated appear to be derived from China, belonging either to basal or L84S clades, the European clades, such as D614G/Q57H, tend to associate with most of the subsequent increase in infected people in the United States.
Geographic and Genomic Distribution of SARS-CoV-2 Mutations.
5Result: Specifically, the four mutations C241T, C3037T, C14408T, and A23403G are observed in all samples from the clade ""G"" (named after the Spike D614G mutation) and its two derivative GH (further characterized by the ORF3a:Q57H mutation) and GR (affected by the trinucleotide mutation in the Nucleocapsid gene, inducing a RG203KR mutation)."
Result: Currently, the vastly prevalent genome in North America is GH (mutations in Spike D614G and ORF3a Q57H), accounting for more than 50% sequences submitted.
Table:
Characterizing SARS-CoV-2 mutations in the United States.
Introduction: Based on genotyping results, top eight missense mutations (i.e., 14408C>T-(P323L), 23403A>G-(D614G), 25563G>T-(Q57H), 1059C>T-(T85I), 28144T>C-(L84S), 17858A>G-(Y541C), 17747C>T-(P504L), and 27964C>T-(S24L)) are identified, in addition to three synonymous mutations (i.e., 3037C>T-(F106F), 8782C>T-(
BioAider: An efficient tool for viral genome analysis and its application in tracing SARS-CoV-2 transmission.
PMID: 32904401
2020
Sustainable cities and society
Introduction: Recently, 7 substitution hotspots in SARS-CoV-2, ORF1ab-G10818T (ORF1ab-L3606F), ORF1ab-C8517T, ORF3a-G752T (ORF3a-G251V) S-A1841G (D614G), G171T (Q57H), ORF8-T251C (ORF8-L84S) and N-GGG608_609_610AAC (N-RG203_204KR) have been reported.
Table: Q57H
Discussion: The ORF3a-G171T (Q57H) was located at the transmembranous domain of the 3a protein.
Discussion: et al., but with the additional mutations T265I on ORF1ab, Q57H on ORF3, and the four basic mutations (C241T, C3037T, C14408T, and A23403G).
Characterization of local SARS-CoV-2 isolates and pathogenicity in IFNAR(-/-) mice.
Discussion: SARS-CoV-2 genome sequences available at the public database of the Global Initiative on Sharing All Influenza Data (GISAID) till 02-10-2020 classifies the variants into several clades like (i) L-original lineage, (ii) G-variant of spike protein causing D614S mutation, (iii) S- variant ORF8 responsible for L84S mutation, (iv) V- variant of the ORF3a coding protein N3S responsible for G251V mutation, (v) GH- a G derivative characterized by ORF3a: Q57H mutation, (vi) GR-nucleocapsid gene mutations- R203K and G204R, (vii) O- other combinations that do match from the rest
SARS_CoV_2 mutation literature information.
PMID: 
2020
American journal of clinical pathology
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