literature

SARS_CoV_2 mutation literature information.

New Pathways of Mutational Change in SARS-CoV-2 Proteomes Involve Regions of Intrinsic Disorder Important for Virus Replication and Release.

PMID: 33149541 2020 Evolutionary bioinformatics online

Figure: Mutation Q57H is located in the first of the 3 transmembrane helices at the major hydrophilic constriction of the pore important for channel activity.

Discussion: In addition, a comparison of mutants V13L, Q57H, G196V and G251V and the reference viral strain with delta scores of disorder and binding revealed interesting patterns.

Discussion: The high-entropy mutation Q57H, which follows an entropy expansion mode (Figure 3), is located in the first transmembrane helix at the major hydrophilic constriction of the pore, which is important for ion channel activity.

Large scale genomic analysis of 3067 SARS-CoV-2 genomes reveals a clonal geo-distribution and a rich genetic variations of hotspots mutations.

PMID: 33170902 2020 PloS one

Result: For the four other hotspot mutations were distributed in ORF3a (Q57H and G251V) and nucleocapsid phosphoprotein (R203K and G204R).

Result: In Algeria, the genomes harbored mutations very similar to those in Europe, including two recurrent mutations T265I and Q57H of the ORF3a.

Result: The remainder was found in the core phosphoprotein (S193I, S194L, S197L, S202N, R203K, and G204R), membrane glycoprotein (

Analysis of genomic distributions of SARS-CoV-2 reveals a dominant strain type with strong allelic associations.

PMID: 33184173 2020 Proc Natl Acad Sci U S A

Result: In addition to the three type VI signature SNVs, five additional subtype SNVs with variation frequencies of >0.1 included C1059T (nsp2, T265I), G25563T (ORF3a, Q57H), G28881A (N, R203K), G28882A (N, R203K), and G28883C (N, G204R).

Genetic diversity of SARS-CoV-2 and clinical, epidemiological characteristics of COVID-19 patients in Hanoi, Vietnam.

PMID: 33201914 2020 PloS one

Table: Q57H

Loss of orf3b in the circulating SARS-CoV-2 strains.

PMID: 33205709 2020 Emerging microbes & infections

Figure: (A) Highlight of the Q57H substitution in orf3a and the introduction of premature stop codon in orf3b.

Figure: SARS-CoV-2 orf3a Q57H substitution creates early stop codon of orf3b.

Discussion: For the SARS-CoV-2 orf3a, more than 50 non-synonymous mutations have been identified and the most frequent and dominant one is Q57H.

Potentially adaptive SARS-CoV-2 mutations discovered with novel spatiotemporal and explainable AI models.

PMID: 33357233 2020 Genome biology

Result: 2) consists of the mutation Thr85Ile at the same loop of nsp2, followed by Gln57His in ORF3a; site 57 is predicted to be part of a helix break at the first transmembrane segment.

Result: The fifth branch (12-13) is defined by the Thr85Ile mutation in nsp2 followed by Gln57His in ORF3a.

Full-length genome characterization and phylogenetic analysis of SARS-CoV-2 virus strains from Yogyakarta and Central Java, Indonesia.

PMID: 33391880 2020 PeerJ

Result: Moreover, WGS of virus from patient-1, patient-2 and patient 3 showed nine amino acid mutations in six proteins, including NSP3 (P679S), NSP12 (P323L, A656S), NSP13 (M576I), spike (D614G), NS3 (A54V, Q57H, A99S), and NP (Q160R); four amino acid mutations in four proteins: NSP3 (P822L), NSP12 (P323L

Table: Q57H

Spike protein D614G and RdRp P323L: the SARS-CoV-2 mutations associated with severity of COVID-19.

PMID: 33412760 2020 Genomics & informatics

Result: In ORF3a, 25563G>T mutation at the nucleotide level resulted in Q57H mutation at the amino acid level, and this mutation was more prevalent in severely affected group (26.8%) compared with mildly affected group (10.9%, p = 0.08).

SARS-CoV-2 Genomes From Oklahoma, United States.

PMID: 33613621 2020 Frontiers in genetics

Result: A previously reported deleterious variation in the protein expressed from ORF3a, Q57H, was recorded in Oklahoma-ADDL-1, the genome isolated at the beginning of the pandemic in Oklahoma.

Table: Q57H

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