literature

SARS_CoV_2 mutation literature information.

Mutation profile of SARS-CoV-2 genome in a sample from the first year of the pandemic in Colombia.

PMID: 34933126 2022 Infection, genetics and evolution

Result: We identified Q57H on ORF3a in 184 out of 386 (47.6%) samples; we also found and R203K, R203R, G204R on N gene, in 74 (19.1%), 72 (18.7%), and 72 (18.7%) out of 386 cases, respectively.

Discussion: Discussion: Of those, we reported here the following four: Q57H on ORF3a, and R203K, R203R, G204R on N gene.

D155Y substitution of SARS-CoV-2 ORF3a weakens binding with Caveolin-1.

PMID: 35126886 2022 Computational and structural biotechnology journal

Introduction: G251V and Q57H exhibit severe virulence property.Viral infection consists of several steps starting from viral entry, intracellular trafficking, replication, assembly and then release of the viral particles.

Introduction: The mutation patterns of ORF3a gene have been characterized as largely non-synonymous and increasingly deleterious (Q57H, H93Y, R126T, L127I, W128L, L129F, W131C, D155Y, D173Y, G196V, and G251V).

Table: Q57H

Whole-Genome Sequencing of SARS-CoV-2 Strains from Asymptomatic Individuals in India.

PMID: 35084216 2022 Microbiology resource announcements

Table: Q57H

Mutations in viral nucleocapsid protein and endoRNase are discovered to associate with COVID19 hospitalization risk.

PMID: 35075180 2022 Scientific reports

Table: Q57H

A short plus long-amplicon based sequencing approach improves genomic coverage and variant detection in the SARS-CoV-2 genome.

PMID: 35025877 2022 PloS one

Result: As shown, mutation, i.e.,Q57H in the genomic region that have good uniform sequencing coverage in both assays, was consistently picked up by both short (Panel 3A) as well as long-amplicon data (Panel 3B).

Figure: Blue solid arrows point to examples of three mutations, Q57H, G172V and A2A mutations.

Comparative mutational analysis of SARS-CoV-2 isolates from Pakistan and structural-functional implications using computational modelling and simulation approaches.

PMID: 34968862 2022 Computers in biology and medicine

Result: In these SARS-COV2 isolates, a signature Q57H substitution in ORF3 protein was observed in 23 out of 50 samples which is the second frequent mutation in these Pakistani isolates.

Result: The Q57H substitution in ORF3 co-occurs with two other amino acids mutations K21 N and T223I, in isolates MW447644.1, MW447642.1 respectively.

Result: The accessory protein the ORF3A has one mutation hotspot Q57H (63%).

Reduced levels of convalescent neutralizing antibodies against SARS-CoV-2 B.1+L249S+E484K lineage.

PMID: 34780883 2022 Virus research

Result: Regarding B.1.111 isolates, although both share the mutation pattern characteristic of the B.1.111 lineage (Spike D614G, NS3 Q57H and NSP12 P323L), several divergent genome wide mutations were observed between those isolates, for example, EPI_ISL_794659 have two additional mutations at the S protein (Spike T859I and W152R) (Table 1).

Table: Q57H

Identification of genotypic variants and its proteomic mutations of Brazilian SARS-CoV-2 isolates.

PMID: 34740719 2022 Virus research

Table: Q57H

An Update on Severe Acute Respiratory Syndrome Coronavirus 2 Diversity in the US National Capital Region: Evolution of Novel and Variants of Concern.

PMID: 34272947 2022 Clinical infectious diseases

Result: The most common amino acid substitutions across lineages were S:D614G, NSP12:P323L, NSP2:T85I, and NS3:Q57H.

Discussion: The most common amino acid substitutions were extra-spike and included stable changes (eg, NS3:Q57H) and changes that increased (multiple NSP3 and NS8 changes).

Role of the Microbiome in the Pathogenesis of COVID-19.

PMID: 35433495 2022 Frontiers in cellular and infection microbiology

Introduction: Earliest samples from the USA appeared to have been derived from China and belonged to basal or L84S clades, while subsequent infected samples associated with European clades, such as D614G/Q57H.

Table: Q57H

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