literature

SARS_CoV_2 mutation literature information.

Ongoing global and regional adaptive evolution of SARS-CoV-2.

PMID: 34292871 2021 Proc Natl Acad Sci U S A

Result: Of particular interest seems to be ORF8 Q27*, which is a signature for variants B.1.1.7 and B.1.1.7_E484K and could be epistatically linked to positively selected residues including N R203K and S D614G.

Correlates of SARS-CoV-2 Variants on Deaths, Case Incidence and Case Fatality Ratio among the Continents for the Period of 1 December 2020 to 15 March 2021.

PMID: 34356077 2021 Genes

Result: The NS8_Q27stop mutation was reported at 46.36% in SARS-CoV-2 genome sequences isolated from Europe.

Molecular Epidemiology of SARS-CoV-2 in Diverse Environmental Samples Globally.

PMID: 34442775 2021 Microorganisms

Result: In the ORF8 protein, mutations were found at Q27stop (49.7%) and Y73C (50.2%) (Figure 7 and Figure 8, and Supplementary File S1).

Result: On the other hand, the NS3 and NS8 protein of environmental strains showed frequent mutations at Q57H and Q27stop, respectively.

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.

PMID: 34462752 2021 bioRxiv

Method: Individual point mutations for Alpha (NSP3: P153L, T183I, A890D, I1412T; NSP6: SGF106-108del; NSP12: P323L; Spike: HV69-70del, Y145del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H; ORF8: Q27stop, R52I, Y73C, S84L<

SARS-CoV-2 Variants Detection Using TaqMan SARS-CoV-2 Mutation Panel Molecular Genotyping Assays.

PMID: 34737587 2021 Infection and drug resistance

Result: Out of nine samples, five were B.1.617.2 (Delta) and concordant with sequencing showing mutation in D614G, L452R, P681R, and T478K, two samples were B.1.1.7 (Alpha) showing mutation in D614G, N501Y, delH69V70, Q27stop, and two were B.1.526 (Iota) showing mutation in L452R and D614G (Supplementary Material S5).

Result: The B.1.351 control showed mutation in E484K, D614G, A701V, K417N, N501Y, and L242_244L, B.1.1.7 showed mutations in D614G, delH69V70,

Host Response to SARS-CoV2 and Emerging Variants in Pre-Existing Liver and Gastrointestinal Diseases.

PMID: 34760721 2021 Frontiers in cellular and infection microbiology

Introduction: This variant of B.1.1.7 lineage harbors receptor-binding domain (RBD) N501Y mutation and other mutations including 69/70 deletion, spike P681H, and ORF8 stop codon (Q27stop) mutation.The beta variant (20H/501Y.V2) of B.1.351 lineage harbors spike N501Y, E484K, and K417N/T mutations without 69/70 deletion and is predicted to have emerged in South Africa during October 2020 with potential of global spread.

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