literature

SARS_CoV_2 mutation literature information.

Genotype-phenotype correlation identified a novel SARS-CoV-2 variant possibly linked to severe disease.

PMID: 33506644 2022 Transboundary and emerging diseases

Abstract: A missense (Q271R) and synonymous (R41R) mutation in the S and N proteins, respectively, were identified in 2/27 patients with severe COVID-19 but not in patients with mild or moderate disease (0/86; p = .05, Fisher's Exact Test).

Result: No statistically significant enrichments were identified (two tailed t-test), though missense (Q271R) and synonymous (R41R) mutations in the S and N proteins, respectively, were identified in 2/27 patients with severe COVID-19 but not in patients with mild or moderate disease (0/86; p = .05, Fisher's Exact Test).

Figure: Two mutations, Q271R and

A comprehensive overview of identified mutations in SARS CoV-2 spike glycoprotein among Iranian patients.

PMID: 34896524 2022 Gene

Table: Q271R

Bioinformatics Analysis Unveils Certain Mutations Implicated in Spike Structure Damage and Ligand-Binding Site of Severe Acute Respiratory Syndrome Coronavirus 2.

PMID: 34121839 2021 Bioinformatics and biology insights

Table: Q271R

Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.

PMID: 34307771 2021 Virusdisease

Result: These spike protein mutations are present at both upstream and downstream of the receptor-binding domain (RBD) and the mutation Q271R has been found to affect the secondary structure of the S1 domain.

Table: Q271R

The Novel Coronavirus Enigma: Phylogeny and Analyses of Coevolving Mutations Among the SARS-CoV-2 Viruses Circulating in India.

PMID: 33496683 2020 JMIR bioinformatics and biotechnology

5Result: In addition to 23403A>G (D614G), 3 uncommon mutations, 23374A>G (Q271R), 24933G>T (G1124V), and 22444C>T (D294D), were also observed in the S gene of the ""major group"" (Table 1)."

8Discussion: Certain strains in the ""major group"" displayed 22374A>G (Q271R), 24933G>T (G1124V), and 22444C>T (D294D) changes in the S gene, which were unique to India."

Discussion: Missense mutations,

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