literature

SARS_CoV_2 mutation literature information.

SARS-CoV-2 phase I transmission and mutability linked to the interplay of climatic variables: a global observation on the pandemic spread.

PMID: 35028838 2022 Environmental science and pollution research international

Introduction: Apart from this, L5F was also observed in 37 countries; Q239K, V483A, and D839Y/N/E in Europe; G476S and V483A in the USA; and P1263L in the UK.

Comprehensive annotations of the mutational spectra of SARS-CoV-2 spike protein: a fast and accurate pipeline.

PMID: 32954666 2021 Transboundary and emerging diseases

Table: Q239K

SARS-CoV-2 variants combining spike mutations and the absence of ORF8 may be more transmissible and require close monitoring.

PMID: 33676232 2021 Biochemical and biophysical research communications

Result: Eleven spike mutations were not found associated with ORF8 variants: L8V/W, N234Q, Q239K, L452R, A475V, G476S, V483A, F490L, V615I/F, A831V and D839Y/N/E.

SARS-CoV-2 mutations: the biological trackway towards viral fitness.

PMID: 33928885 2021 Epidemiology and infection

Table: Q239K

Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.

PMID: 34307771 2021 Virusdisease

Table: Q239K

Investigation of nonsynonymous mutations in the spike protein of SARS-CoV-2 and its interaction with the ACE2 receptor by molecular docking and MM/GBSA approach.

PMID: 34346317 2021 Computers in biology and medicine

Table: Q239K

An insertion unique to SARS-CoV-2 exhibits superantigenic character strengthened by recent mutations.

PMID: 32511374 2020 bioRxiv

Method: Two mutants associated with European Covid-19 patients were constructed using CHARMM-GUI: one is the main strain mutant D614G and the other contains four mutations including Q239K, A831V, D614G and D839Y.

SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes.

PMID: 32577641 2020 bioRxiv

Result: First, we investigated Sarbecovirus conservation of 14 amino acids in the spike protein in which mutations appear to be accumulating in the SARS-CoV-2 population, namely D614G, L5F, L8V/W, H49Y, Y145H, Q239K, V367F, G476S, V483A, V615I/F, A831V, D839Y/N/E, S943P, P1263L.

Result: In contrast, L5F, L8V/W, H49Y,

PMID: 32730807 2020 Cell

Result: Although the eight single mutations (i.e., Q239K, V341I, A435S, K458R, I472V, H519P, A831V, and S943T) in both groups A and B do not exist by themselves, they were found to occur in combination with D614G.

Table: Q239K

Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation.

PMID: 32989130 2020 Proc Natl Acad Sci U S A

Method: Two mutants associated with European COVID-19 patients were constructed using CHARMM-GUI: one is the main strain mutant D614G, and the other contains four mutations including Q239K, A831V, D614G, and D839Y.

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