Result: A65S in 83 sequences, A51V in 44 sequences, S67F in 38 sequences, Q18* in 29 sequences, and E19D and T26I were each found in 27 different sequences (Table S2).
SARS-CoV-2 variants combining spike mutations and the absence of ORF8 may be more transmissible and require close monitoring.
PMID: 33676232
2021
Biochemical and biophysical research communications
Result: A single Q18stop/E110stop ORF8 sequence was classified in clade 20A.
Result: Ten sequences with five spike mutations were found associated with Q18stop, in three different combinations and branches of the SARS-CoV-2 phylogeny.
Result: The ORF8 Q18stop mutation was the most frequent in our dataset (n =
Result: The most divergent sequences within the Q18stop/E110stop cluster had five spike mutations and were detected in England.
Result: The most frequent combination of ORF8 mutations included Q18stop and E110stop, found in 241 sequences.