literature

SARS_CoV_2 mutation literature information.

Genomic surveillance reveals the detection of SARS-CoV-2 delta, beta, and gamma VOCs during the third wave in Pakistan.

PMID: 34726786 2021 Journal of medical virology

Result: The delta variant isolates reported following significant mutations: S:L452R (22917 T>G), S:T478K (22995 C>A), S:P681R (23604 C>G), S:D950N (24410 G>A), ORF3a:S26L (25469 C>T), M:I82T (26767 T>C), ORF7a:V82A (27638 T>C), ORF7a:

PMID: 34737587 2021 Infection and drug resistance

Method: They are: S.K417T.AAG.ACG, S.D614G.GAT.GGT, S.E484K.GAA.AAA, S.E484Q.GAA.CAA, S.K417N.AAG.AAT, S.L452R.CTG.CGG, S.N501Y.AAT.TAT, S.P681R.CCT.CGT, S.T20N.ACC.AAC, S.delH69V70, S.delL242.244L, orf8.Q27ST.CAA.TAA,

Neurological pathophysiology of SARS-CoV-2 and pandemic potential RNA viruses: a comparative analysis.

PMID: 34757622 2021 FEBS letters

Abstract: We present new insight into key mutations in SARS-CoV-2 variants B.1.1.7 (P681H) and B.1.617.2 (P681R), which may impact on neuropilin 1 (NRP1) binding and CNS invasion.

Host Response to SARS-CoV2 and Emerging Variants in Pre-Existing Liver and Gastrointestinal Diseases.

PMID: 34760721 2021 Frontiers in cellular and infection microbiology

Abstract: The mutations in the spike protein of VOC are implicated for increased receptor binding (N501Y, P681R) and immune escape (L452R, E484K/Q, T478K/R) to host response.

Introduction: Additionally, this variant has P681R and L452R mutations in the RBD region, with L452R also present in B.1.427/B.1.429 variants found in California, USA, which have been associated with increased transmissibility of virus.

A Novel Strategy for the Detection of SARS-CoV-2 Variants Based on Multiplex PCR-Mass Spectrometry Minisequencing Technology.

PMID: 34787499 2021 Microbiology spectrum

Abstract: Using the nucleic acid sequence of a SARS-CoV-2 nonvariant and a synthetic SARS-CoV-2 variant-carrying plasmid, a matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) method based on the single-base mass probe extension of multiplex PCR amplification products was established to detect 9 mutation types in 7 mutated sites (HV6970del, N501Y, K417N, P681H, D614G, E484K, L452R, E484Q, and P681R) in the receptor-binding domain of the spike protein of SARS-CoV-2 variants.

Method:

Table: P681H/R

SARS-COV-2 Delta variant displays moderate resistance to neutralizing antibodies and spike protein properties of higher soluble ACE2 sensitivity, enhanced cleavage and fusogenic activity.

PMID: 34790980 2021 bioRxiv

Abstract: Finally, the spike proteins of B.1.617 variants are more efficiently cleaved due to the P681R substitution, and the spike of Delta variants exhibited greater sensitivity to soluble ACE2 neutralization, as well as fusogenic activity, which may contribute to enhanced spread of Delta variants.

SARS-CoV-2 Delta (B.1.617.2) Variant: A Unique T478K Mutation in Receptor Binding Motif (RBM) of Spike Gene.

PMID: 34796036 2021 Immune network

Introduction: SARS-CoV-2 delta variant shares three common mutation sites, L452R, D614G, and P681R with SARS-CoV-2 kappa and B.1.617.3 variant (Table 1).

Table: P681R

Implication of SARS-CoV-2 Immune Escape Spike Variants on Secondary and Vaccine Breakthrough Infections.

PMID: 34804022 2021 Frontiers in immunology

Introduction: Downstream P681R mutation in furin cleavage site promotes cleavage and processing of the spike protein and hence the entry efficiency and infectivity of the virus in vitro.

Table: P681R

Mutation-Induced Long-Range Allosteric Interactions in the Spike Protein Determine the Infectivity of SARS-CoV-2 Emerging Variants.

PMID: 34805715 2021 ACS omega

Table: P681R

A rigorous framework for detecting SARS-CoV-2 spike protein mutational ensemble from genomic and structural features.

PMID: 34806033 2021 Current research in structural biology

Result: The linker region consists of variant stretches contributed from three prominent mutations A570D, H655Y, and P681 H/R along with D614G.

Result: The linker region with P681R and H655Y along with D614G were the main amino acid co-occurring substitutions.

Browser Board

Co-occurred Entities

Filtrator