literature

SARS_CoV_2 mutation literature information.

ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker.

PMID: 34433803 2021 Signal transduction and targeted therapy

Method: B.1.1.7: H69 deletion, V70 deletion, Y144deletion, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H.

Molecular Epidemiology of SARS-CoV-2 in Diverse Environmental Samples Globally.

PMID: 34442775 2021 Microorganisms

Abstract: However, the key mutations-N501Y (44.6%), S982A (44.4%), A570D (43.3%), T716I (40.4%), and P681H (40.1%) were also recorded in spike protein.

Result: N501Y and P681H are key mutations in the alpha variant.

Result: The most common amino acid substitutions were D614G (83.4%) followed by N501Y (44.6%), S982A (44.4%), A570D (43.3%), T716I (40.4%), and P681H (40.1%) in Spike (S) protein.

Novel Nested-Seq Approach for SARS-CoV-2 Real-Time Epidemiology and In-Depth Mutational Profiling in Wastewater.

PMID: 34445204 2021 International journal of molecular sciences

Result: According to the % frequencies of the genetic markers A570D (23271C>A), D614G (23403A>G), P681H (23604C>A), T716I (23709C>T), S982A (24506T>G), and D1118H (24914GG>C), the Beta.1.1.7/alpha lineage VOC was detected in 80.6% +- 8.3 (mean +- SE), (median of 80.8%) of the total sequencing reads.

Emergence and spread of the potential variant of interest (VOI) B.1.1.519 of SARS-CoV-2 predominantly present in Mexico.

PMID: 34448936 2021 Archives of virology

Introduction: A phylogenomic analysis of genomic sequences using the Nextstrain tool showed that the viruses in the lineage B.1.1.519 (B.1.1.1.222+T478K+P681H+T732A) group independently of the lineage B.1.1.222 sequences, strongly suggesting that this variant should be classified as a variant of interest (VOI).

Introduction: Finally, two variants with interesting features were identified in this study: first, 13 sequences belonging to the B.1.1.222 lineage without the T478K mutation, but harboring the T732A mutation and the 69-70 deletion in the spike protein, the latter being a characteristic mutation of the B.1.1.7 VOC first detected in the UK; and second, 11 sequences corresponding to four lineages differing from B.1.1.519 (

Table: P681H

Predominance of the SARS-CoV-2 Lineage P.1 and Its Sublineage P.1.2 in Patients from the Metropolitan Region of Porto Alegre, Southern Brazil in March 2021.

PMID: 34451453 2021 Pathogens (Basel, Switzerland)

Discussion: Additionally, B.1.1.7 carries the P681H substitution in the furin-cleavage site and multiple VOIs bear the L452R substitution.

Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany.

PMID: 34452356 2021 Viruses

Result: Intriguingly, one of the genomes (EPI_ISL_1567985) encoded S-L452R, S-N501Y, and S-G1219V associated with six other amino acid changes in the spike (A570D, D614G, P681H, T716I, S982A, I1221V), most interestingly comprising D614G and also P681H (Figure 4B).

Monitoring SARS-CoV-2 Populations in Wastewater by Amplicon Sequencing and Using the Novel Program SAM Refiner.

PMID: 34452511 2021 Viruses

Result: Sequences from the S1S2 amplicon matched lineage B.1.1.7 with '1841G(D614G) 2042A(P681H) 2147T(T716I)', lineage P.1 with '1841G(D614G) 1963T(H655Y) 2063T(A688V)' or the B.1 lineage with only the now ubiquitous D614G variation (Supplementary 12).

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.

PMID: 34462752 2021 bioRxiv

Method: Individual point mutations for Alpha (NSP3: P153L, T183I, A890D, I1412T; NSP6: SGF106-108del; NSP12: P323L; Spike: HV69-70del, Y145del, N5

Result: It should be noted that the Alpha variant also has a spike mutation at amino acid position 681 (P681H), which may contribute to the increase in spike cleavage when compared with the wild-type USA/WA1-2020 virus; however, a recent study showed that mutation P681H alone did not enhance viral fitness or transmission.

Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants.

PMID: 34465019 2021 mBio

Result: Another mutation (nonsynonymous mutation P681H) was observed in the S protein of the B.1.1.7 lineage.

Table: P681H

Phylogenicity of B.1.1.7 surface glycoprotein, novel distance function and first report of V90T missense mutation in SARS-CoV-2 surface glycoprotein.

PMID: 34466389 2021 Meta gene

Result: Having linked variants V18 and V22 together, as Ward's algorithm applied on Jaccard and Sorensen-Dice did, minimum edit distance equals three, as P812L non-defining substitution and deletion of defining substitutions: P681H, S982A mutually differ V18/V22.

Discussion: Given that P681H mutation enhances SARS-CoV-2 binding affinity towards the cell that results in increased infectivity, the absence of P681H mutation for V22, V9 and V23 may result in reduced infectivity.

Discussion: The absence of P681H mutation in this case can be associated to decreased SARS-CoV-2 binding affinity towards host cell, what is expected to result in reduced infectivity and mild up to moderate clinical presentation.

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