literature

SARS_CoV_2 mutation literature information.

The Impact on Infectivity and Neutralization Efficiency of SARS-CoV-2 Lineage B.1.351 Pseudovirus.

PMID: 33917138 2021 Viruses

Introduction: In the case of B.1.1.7, a series of mutations in eight sites including D614G appeared in the spike protein: Delta69Delta70, Delta144Delta145, N501Y, A570D, P681H, T716I, S982A, and D1118H (; GISAID, accessed on 1 December 2020).

Emergence in southern France of a new SARS-CoV-2 variant harbouring both N501Y and E484K substitutions in the spike protein.

PMID: 33918332 2021 Microorganisms

Introduction: Lineage B.1.1.7 has seventeen lineage-defining mutations including a deletion at positions 69/70 (Delta69/70) and 144, and substitutions N501Y and P681H in S.

Mutation Signatures and In Silico Docking of Novel SARS-CoV-2 Variants of Concern.

PMID: 33925854 2021 Microorganisms

Result: In addition, the UK-VOC contains several nonsynonymous mutations that cause seven aa substitutions at positions N501Y, A570D, D614G, P681H, T716I, S982A, D1118H in S-protein, in which N501Y mutation occurs in the key residue of RBD.

Discussion: Along with the N501Y mutation in UK-VOC, it is speculated that the combination of the P681H mutation in the furin cleavage site and deletion of two amino acids at positions 69-70, which can alter the homology of the S-protein, is likely enhancing the transmissibility of SARS-CoV-2 and res

SARS-CoV-2 mutations: the biological trackway towards viral fitness.

PMID: 33928885 2021 Epidemiology and infection

Introduction: P681H mutation lies near the furin cleavage site and might interfere with viral infectivity and transmission.

Introduction: VUI202012/01 had eight mutations in S protein of which N501Y, P681H, Delta69 and Delta70 have potential implications on viral infectivity.

Table: P681H

Preliminary report on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike mutation T478K.

PMID: 33951211 2021 Journal of medical virology

Result: The other two are P681H and T732A, with 93.8% and 88.7% co-occurrence with S:T478K, respectively (Table 1).

Table: P681H

Structural Consequences of Variation in SARS-CoV-2 B.1.1.7.

PMID: 33969357 2021 Journal of cellular immunology

Result: P681H represents a potentially important difference between Wuhan-Hu-1 sequence and UK variant B.1.1.7.

Will Mutations in the Spike Protein of SARS-CoV-2 Lead to the Failure of COVID-19 Vaccines?

PMID: 33975397 2021 Journal of Korean medical science

Introduction: The UK SARS-CoV-2 B.1.1.7 variant is defined by multiple spike (S) protein changes (deletion 69-70, delet

Method: There were 13 nonsynonymous mutations with a total frequency of > 1,000, and three mutations that are of interest, including D614G, A222V, L18F, S477N, N439K, S98F, L5F, A262S, P272L, P681H, D1163Y, E583D, G1167V, Y453F, E484K, and N501Y.

Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines.

PMID: 34021265 2021 Cell research

Introduction: 501Y.V1 is associated with a set of mutations in its spike (S) protein, including DeltaH69/V70 and DeltaY144 in N-terminal domain (NTD), N501Y in receptor-binding domain (RBD), and P681H near the furin cleavage site.

Implications of the Novel Mutations in the SARS-CoV-2 Genome for Transmission, Disease Severity, and the Vaccine Development.

PMID: 34026780 2021 Frontiers in medicine

Introduction: (b) P681H mutation located within the RBD and has biological significance.

Introduction: The B.1.1.7 variant-specific non-synonymous mutations and deletions have been detected in the spike protein including deletion 69-70, deletion 144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H.

E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil.

PMID: 34044192 2021 Infection, genetics and evolution

Introduction: N501Y is one of the key contact residues interacting with hACE2 and P681H is one of four residues comprising the insertion that creates a furin-like cleavage site between S1 and S2, which is not found in closely-related coronaviruses.

Introduction: Two substitutions present in this lineage deserve special attention: N501Y in the Receptor Binding Domain (RBD) of S1 and P681H near the polybasic RRAR sequence in the furin-like cleavage region.

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