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 SARS_CoV_2 mutation literature information.


  Prediction of the Effects of Variants and Differential Expression of Key Host Genes ACE2, TMPRSS2, and FURIN in SARS-CoV-2 Pathogenesis: An In Silico Approach.
 PMID: 34720581       2021       Bioinformatics and biology insights
Result: No significant change was found in binding energy as well as in interactions for the spike protein mutants P681L, P681H, P681S, P681T, R682W, R682Q, R682L, R683Q, R683P, R683L, A684E, A684P, A684T, A684S, A684V, R685C, R685G, and R685S.


  Characterization of SARS-CoV-2 Variants N501Y.V1 and N501Y.V2 Spike on Viral Infectivity.
 PMID: 34722330       2021       Frontiers in cellular and infection microbiology
Result: The results indicated that pseudovirions bearing HV69-70 deletion, 144 deletion, E484K, D614G, P681H, S982A or D1118H single-site mutations were more stable than SARS-CoV-2 WT, whereas A570D and T716I mutations decrease the stability of SARS-CoV-2 pseudovirion.
Figure: The S protein of N501Y.V1 include nine mutations (HV69-70 del, 144 del, N501Y, D614G, P681H, T716I, S982A, and D1118H), N501Y.V2 include ten mutations (


  Neurological pathophysiology of SARS-CoV-2 and pandemic potential RNA viruses: a comparative analysis.
 PMID: 34757622       2021       FEBS letters
Abstract: We present new insight into key mutations in SARS-CoV-2 variants B.1.1.7 (P681H) and B.1.617.2 (P681R), which may impact on neuropilin 1 (NRP1) binding and CNS invasion.


  Epidemiology of COVID-19: An updated review.
 PMID: 34759999       2021       Journal of research in medical sciences
Table: P681H


  Host Response to SARS-CoV2 and Emerging Variants in Pre-Existing Liver and Gastrointestinal Diseases.
 PMID: 34760721       2021       Frontiers in cellular and infection microbiology
Introduction: This variant of B.1.1.7 lineage harbors receptor-binding domain (RBD) N501Y mutation and other mutations including 69/70 deletion, spike P681H, and ORF8 stop codon (Q27stop) mutation.The beta variant (20H/501Y.V2) of B.1.351 lineage harbors spike N501Y, E484K, and K417N/T mutations without 69/70 deletion and is predicted to have emerged in South Africa during October 2020 with potential of global spread.


  CRISPR-Cas12a-Based Detection for the Major SARS-CoV-2 Variants of Concern.
 PMID: 34787487       2021       Microbiology spectrum
Method: The SARS-CoV-2 target sequences include (i) the wild-type (WT) gene fragment of S protein (S; nucleotides [nt] 21,563 to 25,384; GenBank accession number MN908947); (ii) the mutant gene fragments of S protein, including mutations L5F, D80A, D215G, R246I, K417N, L452R/Q, Y453F, T478K, E484Q/K, N501Y, A570D, D614G, P681H, A701V, T716I,


  A Novel Strategy for the Detection of SARS-CoV-2 Variants Based on Multiplex PCR-Mass Spectrometry Minisequencing Technology.
 PMID: 34787499       2021       Microbiology spectrum
Method: The S gene mutation plasmids (plasmid 1, containing the HV69-70del, K417N, E484K, N501Y, D614G, and P681H mutations, and plasmid 2, containing the L452R, E484Q, and P681R mutations) of SARS-CoV-2 variants (Alpha, Beta, Iota, Epsilon, Gamma, and Delta) were synthesized by Sangon Biotech (Shanghai, China).
Method: The S-F1/R1 amplification product contained one mutation type (HV69-70del), the S-F2/R2 amplification product contained five mutation types (K417N, E484K, E484Q, N501Y, and L452R), and


  SARS-CoV-2 Delta (B.1.617.2) Variant: A Unique T478K Mutation in Receptor Binding Motif (RBM) of Spike Gene.
 PMID: 34796036       2021       Immune network
Table: P681H


  The Development of SARS-CoV-2 Variants: The Gene Makes the Disease.
 PMID: 34940505       2021       Journal of developmental biology
Introduction: P681R is located in the S1/S2 furin-cleavage site, the same residue affected in the P681H substitution found in the Alpha variant.
Introduction: Although P681H initially raised much interest, it has not yet been found to significantly impact viral fitness (see Box 1).
Introduction: Different mutations have been observed in this residue, such as the P681H mutation in the Alpha variant, P681R in Delta and DeltaP681 in the Indian lineage B.1.617 (Table 2).


  Semi-Supervised Pipeline for Autonomous Annotation of SARS-CoV-2 Genomes.
 PMID: 34960694       2021       Viruses
Result: This includes observations of deletions early in the S protein and differentiation between substitutions P681H, which is a mutation of interest, and P681R.



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