literature

SARS_CoV_2 mutation literature information.

Preliminary report on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike mutation T478K.

PMID: 33951211 2021 Journal of medical virology

Result: The other two are P681H and T732A, with 93.8% and 88.7% co-occurrence with S:T478K, respectively (Table 1).

Table: P681H

Structural Consequences of Variation in SARS-CoV-2 B.1.1.7.

PMID: 33969357 2021 Journal of cellular immunology

Result: P681H represents a potentially important difference between Wuhan-Hu-1 sequence and UK variant B.1.1.7.

Will Mutations in the Spike Protein of SARS-CoV-2 Lead to the Failure of COVID-19 Vaccines?

PMID: 33975397 2021 Journal of Korean medical science

Introduction: The UK SARS-CoV-2 B.1.1.7 variant is defined by multiple spike (S) protein changes (deletion 69-70, delet

Method: There were 13 nonsynonymous mutations with a total frequency of > 1,000, and three mutations that are of interest, including D614G, A222V, L18F, S477N, N439K, S98F, L5F, A262S, P272L, P681H, D1163Y, E583D, G1167V, Y453F, E484K, and N501Y.

Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines.

PMID: 34021265 2021 Cell research

Introduction: 501Y.V1 is associated with a set of mutations in its spike (S) protein, including DeltaH69/V70 and DeltaY144 in N-terminal domain (NTD), N501Y in receptor-binding domain (RBD), and P681H near the furin cleavage site.

Implications of the Novel Mutations in the SARS-CoV-2 Genome for Transmission, Disease Severity, and the Vaccine Development.

PMID: 34026780 2021 Frontiers in medicine

Introduction: (b) P681H mutation located within the RBD and has biological significance.

Introduction: The B.1.1.7 variant-specific non-synonymous mutations and deletions have been detected in the spike protein including deletion 69-70, deletion 144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H.

E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil.

PMID: 34044192 2021 Infection, genetics and evolution

Introduction: N501Y is one of the key contact residues interacting with hACE2 and P681H is one of four residues comprising the insertion that creates a furin-like cleavage site between S1 and S2, which is not found in closely-related coronaviruses.

Introduction: Two substitutions present in this lineage deserve special attention: N501Y in the Receptor Binding Domain (RBD) of S1 and P681H near the polybasic RRAR sequence in the furin-like cleavage region.

Convalescent-Phase Sera and Vaccine-Elicited Antibodies Largely Maintain Neutralizing Titer against Global SARS-CoV-2 Variant Spikes.

PMID: 34060334 2021 mBio

Introduction: N501Y is one of six ACE2 contact residues and has been shown to increase the affinity for ACE2 by forming a hydrogen bond with Y41, the Delta69-70 deletion in the N-terminal domain (NTD) is found in multiple independent lineages, and P681H lies adjacent to the furin cleavage site, suggesting a role in spike protein processing.

Introduction: The B.1.1.7 lineage (VOC-202012/01) variant identified in patients in the United Kingdom encodes a spike protein with 8 mutations in addition to D614G (Delta69-70, Y144Del, N501Y, A570D, P681H, T716I, S982A, and D1118H).|mg

Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike's Dynamics.

PMID: 34064904 2021 Viruses

Discussion: Recently, the United Kingdom has reported that a large proportion of new cases in South East England belonged to a new single phylogenetic cluster defined by multiple spike protein mutations (deletions 69-70 and 144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H).

Discussion: The B1.525 variant harbors a Q677H mutation, the variant B1.1.7 reported in the United Kingdom carries A570D and P681H mutations, the P1 variant from Brazil shows the H655Y mutation, and the recently reported B.1.617 strain in India shows a P681R cha

Molecular Analysis of SARS-CoV-2 Circulating in Bangladesh during 2020 Revealed Lineage Diversity and Potential Mutations.

PMID: 34065789 2021 Microorganisms

Result: Furthermore, other potential mutations (L5F, N354S, A520K, Q675H/R, Discussion: Bangladeshi strains exhibited other S protein mutations or variants, as well as combined variants, such as L5F, L18F, N354S, A520K, Q675H/R, P681H/R, L5F + D614G, and D614G + M1229Y, which have been previously linked with increased infectivity under experimental setups and may have significant biological properties in response to natural infection.

Mutations in the B.1.1.7 SARS-CoV-2 Spike Protein Reduce Receptor-Binding Affinity and Induce a Flexible Link to the Fusion Peptide.

PMID: 34066729 2021 Biomedicines

Introduction: This variant is characterized by several amino acid deletions and exchanges, with most of the protein-coding mutations found within the surface-anchored spike (S) protein of the virus: del69-70HV, del144Y, N501Y, A570D, D614G, P681H, T761I, S982A, D1118H (Figure S1a).

Method: These were N501Y, A570D, D614G, P681H, T716I, S982A and D1118H.

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