literature

SARS_CoV_2 mutation literature information.

The Antigenicity of Epidemic SARS-CoV-2 Variants in the United Kingdom.

PMID: 34220844 2021 Frontiers in immunology

Introduction: Since December 2020, the VOC-202012/01 (VOC-202012/01 variant, including multiple mutations 69-70del, 144/145del, N501Y, A570D, P681H, T716I, S982A, and D1118H) has been increasing rapidly.

Discussion: Eight of the 17 mutations in the VOC-202012/01 variant are located in the spike protein, including 69-70del, 144/145del, N501Y, A570D, P681H, T716I, S982A, and D1118H.

Discussion: Furthermore, as the P681H mutation is immediately adjacent to the Furin cleavage site, the proteolyt

Updated SARS-CoV-2 single nucleotide variants and mortality association.

PMID: 34245452 2021 Journal of medical virology

Discussion: The set of signature variants includes 8 changes from S protein: deletion 69-70, deletion 144-145, N501Y (A23063T), A570D (C23271A), D614G, P681H (C23604A), T716I (C23709T), S982A (T24506G), D1118H (G24914C).

Evolutionary insights into the furin cleavage sites of SARS-CoV-2 variants from humans and animals.

PMID: 34258664 2021 Archives of virology

Discussion: Although the P681H mutation was the most prevalent FCS mutation in human SARS-CoV-2 isolates, it was also detected in different animal species, including dog (n = 3), cat (n = 2), monkey (n = 2), lion (n = 1), tiger (n = 1), and leopard (n = 1), as well as in environmental samples (n = 167), indicating that this mutation may have an impact on virus transmissibility and fitness.

Discussion: Deep analysis of SARS-CoV-2 S protein sequences revealed multiple substitutions, including S680P/F, P681H/R/S/L, R682G/Q/W, R683G/P, A684E/S/T/V, S686R, V687I, and A688S/V (Table 1

Coding-Complete Genome Sequences of 11 SARS-CoV-2 B.1.1.7 and B.1.351 Variants from Metro Manila, Philippines.

PMID: 34264104 2021 Microbiology resource announcements

Table: P681H

Detection of Representative Mutant Strains and a Case of Prolonged Infection by SARS-CoV-2 with Spike 69/70 Deletion in Japan.

PMID: 34267528 2021 Infection and drug resistance

Abstract: The mutants of the spike region of SARS-CoV-2, such as N501Y, E484K, P681H, and deletion H69/V70 (del 69/70), were studied in 25 COVID-19 patients admitted from December 2020 to April 2021; there were no patients with N501Y and P681H, but nine patients had E484K alone.

Introduction: However, the prevalence of other mutants, such as P681H and del69/70, is unknown.

Introduction: In the B1.1.7 lineage, P681H and deletion of H69/V70 (del 69/70) were also reported to be resistant to the anti-viral agent remdesivir and to have an allosterically changed

SARS-CoV-2 testing and sequencing for international arrivals reveals significant cross border transmission of high risk variants into the United Kingdom.

PMID: 34278277 2021 EClinicalMedicine

Introduction: P681H is adjacent to the furin cleavage site, potentially affecting membrane fusion.

A Simple Reverse Transcriptase PCR Melting-Temperature Assay To Rapidly Screen for Widely Circulating SARS-CoV-2 Variants.

PMID: 34288729 2021 Journal of clinical microbiology

Introduction: The B.1.1.7 variant has a number of mutations in the spike protein, including single-nucleotide polymorphisms (SNPs) resulting in N501Y, A570D, D614G, and P681H mutations and deletions at amino acids 69 and 70 and 144Y.

Ongoing global and regional adaptive evolution of SARS-CoV-2.

PMID: 34292871 2021 Proc Natl Acad Sci U S A

Figure: Black nodes correspond to key amino acid substitutions S L18F, S A222V, S S477N, S N501Y, S D614G, S P681H, S T716I, N R203K, and N G204R.

Trajectory of Growth of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants in Houston, Texas, January through May 2021, Based on 12,476 Genome Sequences.

PMID: 34303698 2021 The American journal of pathology

Result: Eighteen patients with this N440K replacement were identified, and 10 patients had the identical combination of spike amino acid replacements: L18R, T95I, R158S, N440K, D614G, P681H, A688V, S735A, and T1027I.

Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.

PMID: 34307771 2021 Virusdisease

Table: P681H

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