Discussion: In addition, 20% of SNP changes occurred in the S gene, such as p.Asp501Tyr, p.Pro681His, and p.Pro681Arg.
Discussion: Previous SARS-CoV-2 studies suggest that the p.Pro681His mutation is associated with enhanced systemic infection and increased membrane fusion.
Discussion: The p.Pro681His mutation has unique and emerging characteristics with a significant exponential increase in worldwide frequency.
Discussion: The p.Pro681His mutation is the characteristic of the n
Phylodynamic Pattern of Genetic Clusters, Paradigm Shift on Spatio-Temporal Distribution of Clades, and Impact of Spike Glycoprotein Mutations of SARS-CoV-2 Isolates from India.
PMID: 35017872
2021
Journal of global infectious diseases
Result: Figure 4 shows prevalent mutations such as D614G, Q677H and P681H originated during March, April and July respectively and their appearance was observed till the end of the year 2020.
Result: Many amino acid mutations were observed to be region specific namely F32Y, T33K and G35Q mutations (in Karnata
Figure: D614G, Q677H and P681H mutations originated during the first half of the year and their appearance was observed throughout the year; L54F, K77M and P812 L mutations emerged during the first half of the year but absent after few months of their appearance.
Tracking SARS-CoV-2 Spike Protein Mutations in the United States (January 2020-March 2021) Using a Statistical Learning Strategy.
Result: It is natural to name the haplotype T478K-D614G-P681H-T732A as a B.1.1.222.
Result: It is plausible that the P681H mutation increases the flexibility of the S1/S2 cleavage segment, which might lead to enhanced cleavage and infectivity.
Result: The P681H mutation occurs in the S1/S2 cleavage segment of the Spike protein, which is typically not resolved in cryo-electron microscopy or X-ray diffraction experiments.
A Genomic Snapshot of the SARS-CoV-2 Pandemic in the Balearic Islands.
Discussion: This lineage is defined by 14 amino acid changes and three deletions, including six amino acid substitutions and two deletions in the spike protein: S:DeltaH69-V70, S:DeltaY144, S:N501Y, S:A570D, S:P681H, S:T716I, S:S982A, and S:D1118H and it has been related with some evolutionary advantages such as an increased transmissibility.
Molecular Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Isolates From Central Inner Sardinia.
Result: The III wave was characterized by the appearance of the subset of mutations that distinguish the B.1.1.7 lineage such as H69_V70del, Y144del, N501Y, A570D, P681H, T716I, S982A, and D1118H.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Frontiers in public health
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