literature

SARS_CoV_2 mutation literature information.

AutoVEM2: A flexible automated tool to analyze candidate key mutations and epidemic trends for virus.

PMID: 34512928 2021 Computational and structural biotechnology journal

Result: Among the 17 sites, 11 caused amino acid changes, of which 5 mutation sites were located on the S protein (including N501Y, P681H, T716I, S982A, and D1118H) (Table 3).

In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2.

PMID: 34534263 2021 PLoS pathogens

Method: We used the following amino acids replacements and deletions in Spike for each lineage-based COG-UK defined changes for each l

Result: Importantly, in our in vitro passaged viruses we observed both synonymous and non-synonymous substitutions occurring at the same sites within spike (H69R, E484D, N501T, H655Y, P681P) as those identified in the emerging SARS-CoV-2 variants of concern (Alpha (B.1.1.7): Delta69/70, N501Y, P681H; Gamma (P.1): E484K, N501Y, H655Y; Beta (B.1.351): E484K, N501Y) (Fig 4).

Contribution of single mutations to selected SARS-CoV-2 emerging variants spike antigenicity.

PMID: 34536797 2021 Virology

Result: Examining each variant and their single mutations more closely, though full B.1.1.7 Spike did not significantly reduce plasma binding in previously-infected vaccinated individuals, three of its single mutations, DeltaY144, P681H, and S982A significantly affected plasma recognition.

Result: Mutations apparently contributing to the reduction of plasma recognition of the B.1.1.7 Spike are the DeltaY144 deletion in the NTD, P681H and T716I near the S1/S2 cleavage site.

The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages.

PMID: 34537136 2021 Cell

Result: Additionally, whereas a convergent A701V mutation is also found in the B.1.526 and S/E484K carrying lineage that was first identified in New York, P681H is found in the S/E484K and S/N501Y carrying P.3 lineage first identified in the Philippines, and both S/H655Y and S/P681H are found in the highly mutated S/E484K carrying A.VOI.V2 lineage first identified in Tanzanian travelers.

Result: Any of H655Y, P681H, A701V, or T716I might directly impact the efficiency of viral entry into host cells.

Result: SARS-CoV-2 variants with deletions of the furin cleavage

Case Report: Paucisymptomatic College-Age Population as a Reservoir for Potentially Neutralization-Resistant Severe Acute Respiratory Syndrome Coronavirus 2 Variants.

PMID: 34544043 2021 The American journal of tropical medicine and hygiene

Conclusion: Of these, 56 (60%) sequences were of B.1.1.7/20I/501Y.V1 lineage; four isolated from early February through mid-March were of a B.1.1.519/20B lineage including three sequences with the T478K mutation that has been reported from the designated BV-2 (hCoV-19/USA/GHRC-BV2-EQ04518823/2021, hCOV-19/USA/GHRC-BV2-EQ04526485/2021 and hCoV-19/USA/GHRC-BV2-EQ04531246/2021), a lineage was first detected in the United States, but subsequently became common in Canada and Mexico with a peak near the end of March 2021; 22 were B.1.2/20G including BV-3, a genome very similar to other local 20G lineage sequences, except for the addition of a cluster of four spike mutations (P681H, T716I, S982A, and D1118H) that were not present in any local 20G lineage genomes, but were all present on all local 20

Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters.

PMID: 34545191 2021 Communications biology

Introduction: These spike mutations include the deletion H69/ V70, which has arisen in multiple independent lineages and is suggested to associate with increased infectivity and evasion of the immune response; the substitution N501Y, which enhances binding affinity for the human ACE2 receptor and might affect viral transmissibility; and the mutation P681H, which is adjacent to the S1/S2 furin cleavage site in spike and might have an impact on viral infectivity.

The in vitro and in vivo efficacy of CT-P59 against Gamma, Delta and its associated variants of SARS-CoV-2.

PMID: 34547629 2021 Biochemical and biophysical research communications

Method: Pseudoviruses for Gamma, Delta, Epsilon, Kappa, L452R, T478K, and P681H, K417T, E484K, and N501Y were produced.

Result: CT-P59 was less susceptible to L452R, but retained its own neutralizing effect against T478K, and P681H (Table 2 and Supplementary.

Table: P681H

Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants.

PMID: 34549975 2021 Journal of virology

Table: P681H

Emergence and Spread of a B.1.1.28-Derived P.6 Lineage with Q675H and Q677H Spike Mutations in Uruguay.

PMID: 34578382 2021 Viruses

Introduction: The lineage P.3 (former VOI Theta) emerged in the Philippines, and it includes substitutions S:E484K/N501Y/P681H among the lineage-defining mutations; the first sample was collected on 8 January 2021, and later it further spread to the USA, Germany, and Malaysia, among other countries.

Discussion: Moreover, mutations close to or at the polybasic cleavage site at the S1/S2 boundary have been reported in several VOCs and VOIs, including: Alpha (S:P681H), Beta (A701V), Delta (P681R), Eta (Q677H), Iota (A701V), Kappa (P681R), and Theta (P.3, P681H).

Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions.

PMID: 34599175 2021 Nature communications

Result: Despite sharing multiple mutations and deletions with known VOCs (most prominently HV69/70Delta, LLA241/243Delta, S477N, E484K and P681H), lineage B.1.620 does not appear to be of recombinant origin.

Result: Of these, P681H is also located on the outer surface of the spike protein, directly preceding the multibasic S1/S2 furin cleavage site.

Result: The remaining mutations in the spike protein:P681H, T1027I and D1118H:are uncharacterised to the best of our knowledge.

Browser Board

Co-occurred Entities

Filtrator