Result: hCoV-19/Finland/FinD796H/2021 had a very uncommon combination of the S protein mutations, as only 0,04% (535/1204022) of complete genome sequences deposited to Gisaid at 23.4.2021 had a similar combination (S:T95I, S: 144del, S:E484K, S:D614G, S:P681H, and S:D796D&H).
Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using in Silico Approach.
Result: Among the amino acid mutations found in circulating SARS-CoV-2 variants, E484Q/K, P681H/R/L/S, P936Y/N/H, D950H/A/N, and D1118H/Y had a lower T cell immunogenicity than the prototype and S-D614G mutant (Table S1).
Result: At least 3,776 S protein variants belonging to alpha (B.1.1.7) variant lineage were identified, in which all contain 2 deletion events (amino acids 69 to 70 and 144) and 7 mutations (N501Y, A570D, D614G, P681H, T716I, S982A
Prediction of the Effects of Variants and Differential Expression of Key Host Genes ACE2, TMPRSS2, and FURIN in SARS-CoV-2 Pathogenesis: An In Silico Approach.
PMID: 34720581
2021
Bioinformatics and biology insights
Result: No significant change was found in binding energy as well as in interactions for the spike protein mutants P681L, P681H, P681S, P681T, R682W, R682Q, R682L, R683Q, R683P, R683L, A684E, A684P, A684T, A684S, A684V, R685C, R685G, and R685S.
Characterization of SARS-CoV-2 Variants N501Y.V1 and N501Y.V2 Spike on Viral Infectivity.
PMID: 34722330
2021
Frontiers in cellular and infection microbiology
Result: The results indicated that pseudovirions bearing HV69-70 deletion, 144 deletion, E484K, D614G, P681H, S982A or D1118H single-site mutations were more stable than SARS-CoV-2 WT, whereas A570D and T716I mutations decrease the stability of SARS-CoV-2 pseudovirion.
Figure: The S protein of N501Y.V1 include nine mutations (HV69-70 del, 144 del, N501Y, D614G, P681H, T716I, S982A, and D1118H), N501Y.V2 include ten mutations (
Neurological pathophysiology of SARS-CoV-2 and pandemic potential RNA viruses: a comparative analysis.
Abstract: We present new insight into key mutations in SARS-CoV-2 variants B.1.1.7 (P681H) and B.1.617.2 (P681R), which may impact on neuropilin 1 (NRP1) binding and CNS invasion.
Epidemiology of COVID-19: An updated review.
PMID: 34759999
2021
Journal of research in medical sciences
Table: P681H
Host Response to SARS-CoV2 and Emerging Variants in Pre-Existing Liver and Gastrointestinal Diseases.
PMID: 34760721
2021
Frontiers in cellular and infection microbiology
Introduction: This variant of B.1.1.7 lineage harbors receptor-binding domain (RBD) N501Y mutation and other mutations including 69/70 deletion, spike P681H, and ORF8 stop codon (Q27stop) mutation.The beta variant (20H/501Y.V2) of B.1.351 lineage harbors spike N501Y, E484K, and K417N/T mutations without 69/70 deletion and is predicted to have emerged in South Africa during October 2020 with potential of global spread.
CRISPR-Cas12a-Based Detection for the Major SARS-CoV-2 Variants of Concern.
Method: The SARS-CoV-2 target sequences include (i) the wild-type (WT) gene fragment of S protein (S; nucleotides [nt] 21,563 to 25,384; GenBank accession number MN908947); (ii) the mutant gene fragments of S protein, including mutations L5F, D80A, D215G, R246I, K417N, L452R/Q, Y453F, T478K, E484Q/K, N501Y, A570D, D614G, P681H, A701V, T716I,
A Novel Strategy for the Detection of SARS-CoV-2 Variants Based on Multiplex PCR-Mass Spectrometry Minisequencing Technology.
Method: The S gene mutation plasmids (plasmid 1, containing the HV69-70del, K417N, E484K, N501Y, D614G, and P681H mutations, and plasmid 2, containing the L452R, E484Q, and P681R mutations) of SARS-CoV-2 variants (Alpha, Beta, Iota, Epsilon, Gamma, and Delta) were synthesized by Sangon Biotech (Shanghai, China).
Method: The S-F1/R1 amplification product contained one mutation type (HV69-70del), the S-F2/R2 amplification product contained five mutation types (K417N, E484K, E484Q, N501Y, and L452R), and
SARS-CoV-2 Delta (B.1.617.2) Variant: A Unique T478K Mutation in Receptor Binding Motif (RBM) of Spike Gene.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Journal of medical virology
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