Introduction: In this regard, the variant B.1.1.7 was first identified in the United Kingdom, which contains E484K, N501Y, D614G, and P681H mutations in Spike glycoprotein.
Result: For example, it can be seen from both the figures that both P681H and P681R, which are part of the variant of concerns Alpha or B.1.1.7 and Delta or B.1.617.2, have evolved over time globally and for India as well.
Result: Some important hotspot mutations like H69-, V70-, Y144-, A222V, N501Y, A570D, P681H, and P681R identified in this study are associated with the different SARS-CoV-2 v
Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infection.
Method: pS-B.1.1.7 and pS-B.1.351 plasmids were constructed with mutant S genes expressing the spike protein of the B.1.1.7 variant (GenBank: QQH18545.1, containing the H69, V70, and Y145 deletions and N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H mutations) and B.1.351 variant (GenBank: QRI43207.1, containing the L242, A243, and L244 deletions and L18F, D80A, D215G, S305T, K417N, E484K, N501Y, D614G
Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants.
Introduction: The Alpha (B.1.1.7) variant encodes an S protein with nine mutations (del 69-70, Del 144, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H), of which N501Y is in the receptor-binding domain (RBD).
Booster of mRNA-1273 Strengthens SARS-CoV-2 Omicron Neutralization.
Introduction: The Omicron spike in this study contained mutations A67V, Delta69-70, T95I, G142D, Delta143-145, Delta211, L212I, +214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K,
The Development of SARS-CoV-2 Variants: The Gene Makes the Disease.
PMID: 34940505
2021
Journal of developmental biology
Introduction: P681R is located in the S1/S2 furin-cleavage site, the same residue affected in the P681H substitution found in the Alpha variant.
Introduction: Although P681H initially raised much interest, it has not yet been found to significantly impact viral fitness (see Box 1).
Introduction: Different mutations have been observed in this residue, such as the P681H mutation in the Alpha variant, P681R in Delta and DeltaP681 in the Indian lineage B.1.617 (Table 2).
Introduction: In addition, mutation P681H, which is immediately adjacent to the furin S1/S2 cleavage site in spike, could facilitate the processing of the spike protein, and thus improve binding to ACE2.
Introduction: This va
Insights into the Binding of Receptor-Binding Domain (RBD) of SARS-CoV-2 Wild Type and B.1.620 Variant with hACE2 Using Molecular Docking and Simulation Approaches.
Introduction: This variant harbors E484K, N501Y, and P681H mutations in the spike protein, while many other new mutations accompany these mutations, including R346K, Y144T, Y145S, and 146N insertion.
Result: Recently, a new variant of concern, B.1.620, with 23 mutations in total, including S477N, E484K, D614G, and P681H, has been reported.
Semi-Supervised Pipeline for Autonomous Annotation of SARS-CoV-2 Genomes.
Result: This includes observations of deletions early in the S protein and differentiation between substitutions P681H, which is a mutation of interest, and P681R.
SARS-CoV-2 Delta Variant Displays Moderate Resistance to Neutralizing Antibodies and Spike Protein Properties of Higher Soluble ACE2 Sensitivity, Enhanced Cleavage and Fusogenic Activity.
Result: B.1.1.7 and WT(D614G) pseudoviruses bearing P681H also displayed enhanced spike cleavage (Figure 5A), consistent with previous reports.
Result: B.1.429 pseudoviruses that lack P681R or P681H substitutions near the furin cleavage site displayed inefficient spike cleavage, whereas the furin cleavage site ( PRRA)-deleted spike lacked cleavage.
Result: Further investigations of the role of P681H/R substitutions for virus transmissibility and cell-to-cell spread in in vivo animal models are needed.
Result: Our findings agree with several studies reporting enhanced furin cleavage efficiency of B.1.1.7 and B.1.617 spikes bearing
Analysis of Clinical Characteristics and Virus Strains Variation of Patients Infected With SARS-CoV-2 in Jiangsu Province-A Retrospective Study.
Discussion: In addition, 20% of SNP changes occurred in the S gene, such as p.Asp501Tyr, p.Pro681His, and p.Pro681Arg.
Discussion: Previous SARS-CoV-2 studies suggest that the p.Pro681His mutation is associated with enhanced systemic infection and increased membrane fusion.
Discussion: The p.Pro681His mutation has unique and emerging characteristics with a significant exponential increase in worldwide frequency.
Discussion: The p.Pro681His mutation is the characteristic of the n
Phylodynamic Pattern of Genetic Clusters, Paradigm Shift on Spatio-Temporal Distribution of Clades, and Impact of Spike Glycoprotein Mutations of SARS-CoV-2 Isolates from India.
PMID: 35017872
2021
Journal of global infectious diseases
Result: Figure 4 shows prevalent mutations such as D614G, Q677H and P681H originated during March, April and July respectively and their appearance was observed till the end of the year 2020.
Result: Many amino acid mutations were observed to be region specific namely F32Y, T33K and G35Q mutations (in Karnataka); T29I and P681H (Maharashtra); and L7S, L54F, R78M, Q690H, A701T and A879S (Gujarat).
SARS_CoV_2 mutation literature information.
PMID: 
2021
Frontiers in genetics
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