Result: It is natural to name the haplotype T478K-D614G-P681H-T732A as a B.1.1.222.
Result: It is plausible that the P681H mutation increases the flexibility of the S1/S2 cleavage segment, which might lead to enhanced cleavage and infectivity.
Result: The P681H mutation occurs in the S1/S2 cleavage segment of the Spike protein, which is typically not resolved in cryo-electron microscopy or X-ray diffraction experiments.
A Genomic Snapshot of the SARS-CoV-2 Pandemic in the Balearic Islands.
Discussion: This lineage is defined by 14 amino acid changes and three deletions, including six amino acid substitutions and two deletions in the spike protein: S:DeltaH69-V70, S:DeltaY144, S:N501Y, S:A570D, S:P681H, S:T716I, S:S982A, and S:D1118H and it has been related with some evolutionary advantages such as an increased transmissibility.
Molecular Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Isolates From Central Inner Sardinia.
Result: The III wave was characterized by the appearance of the subset of mutations that distinguish the B.1.1.7 lineage such as H69_V70del, Y144del, N501Y, A570D, P681H, T716I, S982A, and D1118H.
SARS_CoV_2 mutation literature information.
PMID: 
2021
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