literature

SARS_CoV_2 mutation literature information.

Genetic variations from successive whole genome sequencing during COVID-19 treatment in five individuals.

PMID: 35035981 2022 New microbes and new infections

Table: P681H

Genomic characterization unravelling the causative role of SARS-CoV-2 Delta variant of lineage B.1.617.2 in 2nd wave of COVID-19 pandemic in Chhattisgarh, India.

PMID: 35065253 2022 Microbial pathogenesis

Discussion:

Discussion: Alpha variant B.1.1.7 was found in one case each from vaccine breakthrough, mild and dead patient category showing nonsynonymous mutations of N501Y, A570D, D614G, P681H, T716I, S982A, D1118H and three deletions of H69del, V70del, and Y144del.

Discussion: Further, P681H in Alpha disrupts the furin cleavage site by changing the Proline to improve the rate of membrane fusion, virus entry, and higher transmissibility, albeit less efficiently than Delta variant manifesting P681R.

Antigenicity of the Mu (B.1.621) and A.2.5 SARS-CoV-2 Spikes.

PMID: 35062348 2022 Viruses

Introduction: The Spike of Mu accumulated the following mutations: insertion in 146N, T95I, Y144T and Y145S, in the N-terminal domain (NTD); R346K, E484K, N501Y in the receptor-binding domain (RBD) and P681H at the S1/S2 interface.

Discriminatory Weight of SNPs in Spike SARS-CoV-2 Variants: A Technically Rapid, Unambiguous, and Bioinformatically Validated Laboratory Approach.

PMID: 35062327 2022 Viruses

Introduction: Announced in December 2020 and probably emerging in November 2020, the Alpha variant, the most commonly i

Result: Considering several parameters, including estimated informedness and amplicon lengths, we observed that the subset comprising the SNPs K417N, N439K, Y453F, S477N, T478K, E484K, N501Y, A570D, H655Y, Q677H, P681H, I692V, A701V, and716I, would lead to a test providing an acceptable compromise between informedness (0.76) and minimal amplicon length (896 bp).

Table: P681H

Drastic decline in sera neutralization against SARS-CoV-2 Omicron variant in Wuhan COVID-19 convalescents.

PMID: 35060426 2022 Emerging microbes & infections

Discussion: However, the P681H in Omicron might be unfavourable to induce fusion.

Unique Evolution of SARS-CoV-2 in the Second Large Cruise Ship Cluster in Japan.

PMID: 35056548 2022 Microorganisms

Abstract: Phylogenetic and haplotype network analysis indicated that the CA strains were derived from a common ancestral strain introduced on the CA cruise ship and spread in a superspreading event-like manner, resulting in several mutations that might have affected viral characte

Result: SARS-CoV-2 obtained novel haplotypes on the CA cruise ship to form the CA-B (G25437T, corresponding to L15F in the ORF3a protein) and CA-C clusters (G25437T+C23604A, corresponding to L15F+P681H in the ORF3a and S protein, respectively), finally obtaining a reversion mutation, T11195C, that was originally found in the Wuhan-Hu-1 strain (Figure 3a).

Modeling SARS-CoV-2 spike/ACE2 protein-protein interactions for predicting the binding affinity of new spike variants for ACE2, and novel ACE2 structurally related human protein targets, for COVID-19 handling in the 3PM context.

PMID: 35013687 2022 The EPMA journal

Discussion: Indeed, while it is expected that mutations at the RBD need to be monitored because those mutations can be responsible for an increase in the binding affinity for the ACE2 receptor, it is matter of debate the increased efficiency in entering host-cells proposed for variants showing supplementary mutations far from the RBD, i.e., D614G or P681H shown by several VoC and other variants of interest or under monitoring (https://www.ecdc.europa.eu/en/covid-19/variants-concern).

Discussion: It is retained that mutations like D614G and P681H, being located in the N-terminal portion of the spike pre-fusion conformation, despite of their relatively great distance from t

Emergence of two distinct variants of SARS-CoV-2 and an explosive second wave of COVID-19: the experience of a tertiary care hospital in Pune, India.

PMID: 35000004 2022 Archives of virology

Result: Importantly, P681H was present in the UK variant B.1.1.7 (Table 2).

Discussion: It is pertinent to note here that a recent increase in COVID-19 cases in New York, USA, was observed to be due to the introduction of B.1.243 lineage strain with P681H and T478K mutations.

Discussion: The rapid global spread of the UK variant with P681H and P681R mutations is well known.

A novel antibody against the furin cleavage site of SARS-CoV-2 spike protein: Effects on proteolytic cleavage and ACE2 binding.

PMID: 35007661 2022 Immunology letters

Discussion: In contrast, the mutation of P681H (Alpha variant) and P681R (Delta variant) significantly increased viral replication and transmission, largely due to increased cleavage of S1/S2 site by furin enzyme.

Dynamics of SARS-CoV-2 Alpha (B.1.1.7) variant spread: The wastewater surveillance approach.

PMID: 35074352 2022 Environmental research

Result: Compared to the Wuhan-Hu-1 variant, VOC Alpha is characterized by the occurrence of 9 genetic markers in the S gene (69-70del, 144del, N501Y, A570D, D614G, P681H, T716I, S928A and D118H).

Result: The relative abundance of each marker from most to least abundant was D614G > A570D > 69-70del and 144del > D1118H > S982A > P681H and T716I > N501Y > E584K

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