literature

SARS_CoV_2 mutation literature information.

Geographic and Genomic Distribution of SARS-CoV-2 Mutations.

PMID: 32793182 2020 Frontiers in microbiology

Table: P504L

Characterizing SARS-CoV-2 mutations in the United States.

PMID: 32818213 2020 Research square

Result: Similar to 27964C>T-(S24L), although 17858A>G-(Y541C), 17747C>T-(P504L) are in the final list in Table 2, more than 87% of t

Result: Table 4 shows that both high-frequency mutations Y541C and P504L have negative folding stability changes, which will destabilize the structure of NSP13.

Result: The other three mutations, 17747C>T-(P504L), 17858A>G-(Y541C), and 28144T>C-(L84S), occur mostly together and have similar numbers of frequencies.

BioAider: An efficient tool for viral genome analysis and its application in tracing SARS-CoV-2 transmission.

PMID: 32904401 2020 Sustainable cities and society

Figure: SARS-CoV (AY291315.1), SARS-CoV-2_referential (EPI_ISL_402119), SARS-CoV-2_NSP13-P504L_Y541C (EPI_ISL_413456), Bat-CoV RaTG13 (MN996532.1), Bat-CoV_RmYN02 (EPI_ISL_412977), Pangolin-CoV (EPI_ISL_410721), MERS-CoV (KC875821.1).

Evaluation of the potency of FDA-approved drugs on wild type and mutant SARS-CoV-2 helicase (Nsp13).

PMID: 32980406 2020 International journal of biological macromolecules

Conclusion: These mutations (P504L and Y541C) caused important exchanges in functional domain 2A of Nsp13 (helicase), a critical enzyme in the life cycle of the virus.

Result: Both P504L and Y541C mutations were in the 2A domain and caused a more hydrophobic 2A domain.

Result: In this way, the difference in sites P504L and Y541C, where there are amino acid changes, can be analyzed with reference to the wild type.

Result: Residue 504 was substituted from proline (wild type) to leucine (mutant) in the mentioned mutation P504L and both residues are non-polar and aliphatic residues.

Result: Two substitutions causing missense mutations (

PMID: 33015402 2020 Heliyon

Table: P504L

Potentially adaptive SARS-CoV-2 mutations discovered with novel spatiotemporal and explainable AI models.

PMID: 33357233 2020 Genome biology

Result:

Result: The haplotype network shows that this mutation is immediately followed by Pro504Leu substitution, which is located at a superficial region of the 2A domain.

Result: The short half-life of this haplotype could indicate that the initial Tyr541Cys mutation was not sustainable by itself, requiring Pro504Leu to persist and expand.

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