literature

SARS_CoV_2 mutation literature information.

Effects of SARS-CoV-2 mutations on protein structures and intraviral protein-protein interactions.

PMID: 33090512 2021 Journal of medical virology

Result: In particular, there were also some mutation combinations, such as P504L/Y541C in nsp13 and R203K/G204R in N (Table S1).

Genetic conservation of SARS-CoV-2 RNA replication complex in globally circulating isolates and recently emerged variants from humans and minks suggests minimal pre-existing resistance to remdesivir.

PMID: 33549572 2021 Antiviral research

Result: Nsp13 substitutions P504L and Y541C decreased in frequency over time.

Table: P504L

Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants.

PMID: 33589648 2021 Communications biology

Introduction: Additionally, three concurrent missense mutations 17747C>T-(P504L), 17858A>G-(Y541C), and 28144T>C-(L84S) tend to fade out, while the other eight concurrent mutations may enhance the infectivity of SARS-CoV-2.

Result: The other three mutations, 17747C>T-(P504L), 17858A>G-(Y541C), and 28144T>C-(L84S), occur mostly together and have similar numbers of frequencies.

Result: Three of the top 11 missense mutations, i.e., 17858A>G-(

The extent of molecular variation in novel SARS-CoV-2 after the six-month global spread.

PMID: 33677109 2021 Infection, genetics and evolution

Abstract: Subclade 1C with the amino acid changes at nsp13 P504L and ORF8 L84S was becoming the second most frequent sub-haplogroup in the world (19.91%) and America (26.29%).

Result: Sub-clade 1C with the amino acid changes at nsp13 P504L and ORF8 L84S was the largest sub-haplogroup in clade 1 among all genome sequences from g

Table: P504L

Whole genome analysis of more than 10 000 SARS-CoV-2 virus unveils global genetic diversity and target region of NSP6.

PMID: 33725111 2021 Briefings in bioinformatics

Table: P504L

Molecular epidemiology analysis of early variants of SARS-CoV-2 reveals the potential impact of mutations P504L and Y541C (NSP13) in the clinical COVID-19 outcomes.

PMID: 33798758 2021 Infection, genetics and evolution

Figure: COVID-19 outcomes in states with different proportions of strains containing variation in Figure: ORF1ab variations (NSP13: P504L and NSP13: Y541C) in SARS-CoV-2.

Figure: Effects of NSP13: P504L and NSP13: Y541C on NSP13 function.

Impact of meteorological parameters and population density on variants of SARS-CoV-2 and outcome of COVID-19 pandemic in Japan.

PMID: 33908339 2021 Epidemiology and infection

Table: P504L

Global variation in SARS-CoV-2 proteome and its implication in pre-lockdown emergence and dissemination of 5 dominant SARS-CoV-2 clades.

PMID: 34147651 2021 Infection, genetics and evolution

Result: Some notable substitutions, co-occurring mutations, deletions and insertions which occur with a low to moderate recurrence and may have a significant influence on the viral pathogenic mechanism are: co-deletion (dependent) of K141, S142 and F143, co-deletion (dependent) of G82 and H83, D75E, co-occurring (dependent) S135N, Y136 deletion and M85 deletion in Nsp1, D268 deletion, G212D, co-occurring (dependent) I559V and P585S, F10L, V198I, P91S, T166I, H237R, T371I, S211F and G339S in Nsp2,

PMID: 34735950 2021 Computers in biology and medicine

Discussion: T85I is noted to co-occur with Q57H, and P504L - with Y541C.

Structural Analysis on the Severe Acute Respiratory Syndrome Coronavirus 2 Non-structural Protein 13 Mutants Revealed Altered Bonding Network With TANK Binding Kinase 1 to Evade Host Immune System.

PMID: 34925297 2021 Frontiers in microbiology

Introduction: The mutations P504L and Y541C in NSP13 were important for different disease outcomes.

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