literature

SARS_CoV_2 mutation literature information.

Global and local mutations in Bangladeshi SARS-CoV-2 genomes.

PMID: 33737154 2021 Virus research

Abstract: Previously reported frequent mutations, such as R203K, D614G, G204R, P4715L and I300F at protein levels were also prevalent in Bangladeshi isolates.

Introduction: Another reported mutation of ORF1ab is P4715 L linked with D614G, which is linked with higher fatality rates in 28 countries and 17 states of the United States.

Result: Among the identified mutations, 28,881 G > A & 28,882 G > A (R203K; N protein), 23,403 A > G (D614G; S glycoprotein

First Report of a SARS-CoV-2 Genome Sequence with a Spike His69-Val70 Deletion and an Asn439Lys Mutation in Morocco.

PMID: 33737349 2021 Microbiology resource announcements

Table: p.Pro4715Leu

SARS-CoV-2 Genome from the Khyber Pakhtunkhwa Province of Pakistan.

PMID: 33748571 2021 ACS omega

Result: Pro4715Leu has been detected in NSP12/RdRP (orf1ab).

SARS-CoV-2 genomic surveillance in Costa Rica: Evidence of a divergent population and an increased detection of a spike T1117I mutation.

PMID: 33905892 2021 Infection, genetics and evolution

Result: The most frequent substitutions were D614G in the Spike and P4715L in the ORF1ab-RdRp both in 98.9% (183) of the genomes.

Table: P4715L

Table: p.Pro4715Leu

Emerging variants of concern in SARS-CoV-2 membrane protein: a highly conserved target with potential pathological and therapeutic implications.

PMID: 33896413 2021 Emerging microbes & infections

Table: P4715L

Report of SARS-CoV-2 B1.1.7 Lineage in Morocco.

PMID: 33888505 2021 Microbiology resource announcements

Table: p.Pro4715Leu

Stability of SARS-CoV-2 Spike G614 Variant Surpasses That of the D614 Variant after Cold Storage.

PMID: 33789940 2021 mSphere

Method: The nonsynonymous mutations include ORF1ab-C794T(T265I), ORF1ab-C14144T(P4715L), S-A1841G(D614G), and ORF3a-G171C(Q57H).

Pan-India novel coronavirus SARS-CoV-2 genomics and global diversity analysis in spike protein.

PMID: 33758785 2021 Heliyon

Result: The four most common mutations were (C241T/5UTR in orf1ab, C3037T in orf1ab (F924F, C14408T P4715L), and D614G in spike protein.

Result: The most common variant observed globally, 3037C > T, ORF1ab: P4715L, RdRp: P323L; and D614G mostly reported from Europe and the USA were also observed in Indian population.

Whole-genome sequencing of SARS-CoV-2 reveals the detection of G614 variant in Pakistan.

PMID: 33755704 2021 PloS one

Result: Five missense mutations were common in all the strains, three in ORF1ab polyprotein (a.a Q2702H, L3606F, P4715L), one in surface glycoprotein (a.a D614G), and one in ORF3a protein (a.a Q57H).

Result: Pakistani strains UN-UVAS-Sialkot/2020 (EPI_ISL_548946) and UN-UVAS-Lahore-I/2020 (EPI_ISL_548942) contained one amino acid change each in ORF1ab (a.a P4715L) and surface glycoprotein (a.a D614G), respectively.

Result: three in ORF1ab (a.a Q2702H,

SARS-CoV-2 genomic analyses in cancer patients reveal elevated intrahost genetic diversity.

PMID: 33738124 2021 Virus evolution

Result: Four genetically linked mutations previously described as the globally dominant haplotype in April 2020 were found in the majority of our consensus sequences: C241T (100%; 5'UTR region), C3037T (98.6%; silent mutation), C14408T (100%; resulting in P4715L/P323L amino acid change in ORF1ab) and A23403G (100%; resulting in D614G amino acid change in S).

Browser Board

Co-occurred Entities

Filtrator