Characterization of altered genomic landscape of SARS-CoV-2 variants isolated in Saudi Arabia in a comparative in silico study.
PMID: 34866979
2021
Saudi journal of biological sciences
Abstract: The most frequently changed nucleotide was C3037T (silent mutation) and A23403G (D614G), each of which occurred in 57 variants out of 58 followed by C14408T (P4715L) and C241T (5'UTR) which were found in 56 and 55 variants respectively.
Result: Our analysis showed that the most frequently changed nucleotide were C3037T (silent mutation) and A23403G (D614G) each of which occurred in 57 variants out of 58, followed by C14408T (P4715L) and C241T (5'UTR) which were found in 56
Molecular Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Isolates From Central Inner Sardinia.
Result: Besides the ubiquitous P4715L, no other substitution found in our dataset displayed a percentage frequency higher than 1% in the global GISAID dataset.
Table: p.Pro4715Leu
Discussion: RdRp P4715L was associated with a drastic change in protein structure and, possibly, function.
Discussion: The identification of the specific missense mutations for each gene highlighted how some substitutions are ubiquitous, such as spike D614G and RdRp P4715L (also known as P323L).
Genome sequencing of SARS-CoV-2 in a cohort of Egyptian patients revealed mutation hotspots that are related to clinical outcomes.
PMID: 33932525
2021
Biochimica et biophysica acta. Molecular basis of disease
Discussio
Discussion: Four highly recurrent mutations (>85%) were observed in S-gene at 23,403 encoding for D614G-spike glycoprotein, in 241-5'UTR and in ORF1a at 3037 (F924*-nsp3) and 14,408 (P4715L-RdRp).
Discussion: In conclusion, we found that the most recurrent P4715L-RdRp and D614G-spike-glycoprotein amino acid alterations were not significantly associated with variations in clinical symptoms, indicating that these mutations are linked to viral spread and persistence within the host regardless of clinical symptoms.
Mutational spectra of SARS-CoV-2 orf1ab polyprotein and signature mutations in the United States of America.
Abstract: Four significant mutations T265I (nsp 2), P4715L (nsp 12), and P5828L and Y5865C (both at nsp 13) were identified in important nonstructural proteins, which function either as replicase or helicase.
Variant analysis of the first Lebanese SARS-CoV-2 isolates.
Result: Three variations were found in the RNA dependent RNA polymerase area: c.14144C > T (p.Pro4715Leu) in 56/61 samples followed by c.16193C > T in 3/61 samples (p.
Table: p.Pro4715Leu
Discussion: Asp614Gly), which also has a replication mutation in ORF1ab P4715L.
Discussion: Virus replication speeds can also be affected by nearly all strains that have D614 G mutation in their protein responsible for Replication (Orf1ab P4715L; RdRp P323L).
In silico comparative genomics of SARS-CoV-2 to determine the source and diversity of the pathogen in Bangladesh.
Result: There were 17 mutations found in more than ten genomes, many of them are among the most frequently found globally, including a cluster of five mutations associated to clades 20A and 20B (lineage B and its sublineages): C241T (5'UTR, 78.1% of the samples), C3037T (nsp3 F924F, 79.5%), C14408T (nsp12 P4715L, 76.3%), A20268G (nsp15 L216L, 68.8%) and A23403G (Spike D614G, 79.5%).
A hijack mechanism of Indian SARS-CoV-2 isolates for relapsing contemporary antiviral therapeutics.
PMID: 33705994
2021
Computers in biology and medicine
Table: P4715L
Discussion: The P4715L mutation was located in a hydrophobic cleft of this protein providing the ability to hijack from remdesivir by the earlier work.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Saudi journal of biological sciences
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