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 SARS_CoV_2 mutation literature information.


  Non-synonymous mutations of SARS-CoV-2 leads epitope loss and segregates its variants.
 PMID: 33049387       2020       Microbes and infection
Abstract: P4715L in RdRp, G251V in ORF3a and S1498F of Nsp3 is associated with the epitope loss that may influence pathogenesis caused by antibody escape variants.
Abstract: It is evident that the D614G mutation in spike glycoprotein and P4715L in RdRp is the important determinant of SARS-CoV-2 evolution since its emergence.
Result: P47


  Analysis of genomic distributions of SARS-CoV-2 reveals a dominant strain type with strong allelic associations.
 PMID: 33184173       2020       Proc Natl Acad Sci U S A
Abstract: To date, type VI, characterized by the four signature SNVs C241T (5'UTR), C3037T (nsp3 F924F), C14408T (nsp12 P4715L), and A23403G (Spike D614G), with strong allelic associations, has become the dominant type.
Method: It is noteworthy that we observed two nucleotides with a nonnegligible variation frequency relative to their neighboring regions: 1) C241T (5' UTR) with a variation frequency of 45.5% (and this nucleotide was in high allelic association with C3037T


  Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity.
 PMID: 33329480       2020       Frontiers in microbiology
Abstract: At the same time, 20A and 20B clades depicted prevalence of four common mutations 241 C > T in 5' UTR, P4715L, F942F along with D614G in the Spike protein.
Result: Among the common variants, the most frequent mutations are 23403 A > G (D614G, S gene), 241 C > T (5' UTR), 14408 C > T (P4715L, RdRP gene), 3037 C > T (F942F, NSP3), 28881 G > A


  Spike protein D614G and RdRp P323L: the SARS-CoV-2 mutations associated with severity of COVID-19.
 PMID: 33412760       2020       Genomics & informatics
Result: This mutation results in a missense mutation P4715L at the amino acid level of ORF1ab polyprotein that ultimately appears as P323L mutation in the RdRp enzyme.
Discussion: The 14408C>T mutation in ORF1ab replaces a proline (P) with leucine (L) at position 4715 (P4715L) of ORF1ab polyprotein which actually appears as a replacement of proline with leucine at position 323 (P323L) of RdRp enzyme.



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