Role of the Microbiome in the Pathogenesis of COVID-19.
PMID: 35433495
2022
Frontiers in cellular and infection microbiology
Table: P4715L
Comparative mutational analysis of SARS-CoV-2 isolates from Pakistan and structural-functional implications using computational modelling and simulation approaches.
PMID: 34968862
2022
Computers in biology and medicine
Result: Among substitution, two in nsp1 (Q63L, G82S), seven in nsp2 (R197C, K261 N, F275L, K292E, V378I, D448 N, V627F) and one deletion at N449, Nine amino acids substitutions in nsp3 (L1174I, T1246I, K1308 N, T1754I, T2016K, T2408F, L2564F, A2619V, Q2702H), two substitutions (
Worldwide SARS-CoV-2 haplotype distribution in early pandemic.
Result: Indeed, in the large majority of cases p.Asp614Gly occurs concomitantly with other variants, in particular with three variants, all characterized by similar frequency and located in the ORF1ab gene: the missense p.Pro4715Leu, the synonymous p.Phe924Phe and the c.-25C>T in the 5' untranslated region.
Table: p.Pro4715Leu
Whole-genome analysis of SARS-CoV-2 in a 2020 infection cluster in a nursing home of Southern Italy.
PMID: 35189404
2022
Infection, genetics and evolution
Table: P4715L
Discussion: A founder haplotype (Hap A) characterized by 6 major SNVs [D614G in the S gene; P4715L, ntC3037T (F924F) and S5398P in Orf1ab gene; ntC26681T (F53F) in the M gene; and ntC241T in the non-coding UTR region] was found in 36 patients.
Discussion: At that time, the spreading of SARS-CoV-2 was characterized by three main differences compared to the Wuhan H1 strain: ntC241T in the 5' untranslated region, D614G in the S gene and, P4715L<
In-silico genomic landscape characterization and evolution of SARS-CoV-2 variants isolated in India shows significant drift with high frequency of mutations.
PMID: 35233173
2022
Saudi journal of biological sciences
Table: P4715L
Circulation of SARS-CoV-2 Variants among Children from November 2020 to January 2022 in Trieste (Italy).
Result: In addition, the Delta-like (EPI_ISL_7698448) strain was compared to the reference SARS-CoV-2 genome isolate (Wuhan-Hu-1, NC_045512.2) (Table 5), and it was assigned to the lineage B.1.617.2 + AY.43 strain using the Pangolin tool based on the presence of the nonsynonymous mutations or deletions A1306S, A1809V, P2046L, P2287S, V2930L, T3255I, T3646A, P4715L, G5063S, L5230I, P5401L, and A6319V in the ORF1ab gene; T19R, G142D, EFR156G (F157Delta, R158Delt
SARS-CoV-2 Mutations and Their Impact on Diagnostics, Therapeutics and Vaccines.
Introduction: Both P4715L and P323L was observed along with S protein D614G mutation, suggesting a co-evolutionary pattern.
Introduction: Nevertheless, studies have reported point mutations in ORF1a/b corresponding to RdRp, which are P4715L, P323L and T265I b.
SARS-CoV-2 Mutations and COVID-19 Clinical Outcome: Mutation Global Frequency Dynamics and Structural Modulation Hold the Key.
PMID: 35386683
2022
Frontiers in cellular and infection microbiology
Result: On the other hand, among the rest of the mutations in the mortality group that did not exhibit any frequency flip (24 mutations), we observed five mutations (C241T, F924F, P4715L, D614G, Q75H) with a high cohort and global distribution.
Discussion: Moreover, the mutation P4715L in RdRp protein affects the viral replication, and the spike mutation D614G influences the viral interaction with the ACE2 receptor, thereby enhancing the overall fitness of the virus.
Conformational Variability Correlation Prediction of Transmissibility and Neutralization Escape Ability for Multiple Mutation SARS-CoV-2 Strains using SSSCPreds.
Introduction: After March 2020, only two mutations, RNA-directed RNA polymerase P323L (ORF1ab P4715L, ORF1b P314L) and spike protein D614G had nearly overwhelmed the original mutation sites ().
Molecular characterization of SARS-CoV-2 from Bangladesh: implications in genetic diversity, possible origin of the virus, and functional significance of the mutations.
Result: The P4715L, one of the highest frequent SNVs, occurred in the RNA dependent RNA polymerase (RdRp) region of ORF1ab polyprotein.
Discussion: Those mutations include 3037C>T (98%), 14408C>T (98%) and 23403A>G (97%) where the last two are non-synonymous mutations (P4715L in ORF1ab or P323L in RdRp and D614G in Spike protein).
SARS_CoV_2 mutation literature information.
PMID: 
2022
Frontiers in cellular and infection microbiology
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