literature

SARS_CoV_2 mutation literature information.

Identification of E484K and other novel SARS-COV-2 variants from the Kingdom of Bahrain.

PMID: 34058304 2021 Microbial pathogenesis

Table: P323L

Molecular Analysis of SARS-CoV-2 Circulating in Bangladesh during 2020 Revealed Lineage Diversity and Potential Mutations.

PMID: 34065789 2021 Microorganisms

Discussion: Many other missense and synonymous mutations found in respective proteins of Bangladeshi virus populations such as ORF1ab/nsp12_P323L, NS3_Q57H, NS8_R52I, N_S194L, N_R203K, and N_G204R, which are also common worldwide.

Discussion: The mutation NSP12_P323L plays a prominent role in protein folding and aggregation.

Molecular epidemiology of SARS-CoV-2 isolated from COVID-19 family clusters.

PMID: 34074255 2021 BMC medical genomics

Table: P323L

Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review.

PMID: 34103090 2021 European journal of medical research

Table: P323L

Structural phylogenetic analysis reveals lineage-specific RNA repetitive structural motifs in all coronaviruses and associated variations in SARS-CoV-2.

PMID: 34141447 2021 Virus evolution

Abstract: However, multiple sequence alignment reveals that the majority of SARS-CoV-2 possesses a variant RSM harboring SL5b C241U, and intriguingly, several variations in the coding sequences of viral proteins, such as Nsp12 P323L, S protein D614G, and N protein R203K-G204R, are concurrently found with such variant RSM.

Result: Several non-synonymous variations are found differential between cluster A and B, for example, C14408U, A23403G, and G28881A-G28882A-G28883C resulting in Nsp12 P323L,

PMID: 34147651 2021 Infection, genetics and evolution

Result: 3 of the clades are due to the high recurrent mutations [Nsp6:L37F (Clade 1), Spike:D614G (Clade 3) and Nsp12:P323L (Clade 4)] and one of the clade is due to the moderately recurring mutation [ORF8:L84S (Clade 2)].

Result: For instance, additional mutations in Spike:D614G (Clade 3a) have led to: Clade 3b (Nsp12:P323L), Clade 3c (Nsp12:P323L and ORF3a:Q57H), Clade 3d (Nsp12:

Multilevel systems biology analysis of lung transcriptomics data identifies key miRNAs and potential miRNA target genes for SARS-CoV-2 infection.

PMID: 34157472 2021 Computers in biology and medicine

Table: P323L

The architecture of the SARS-CoV-2 RNA genome inside virion.

PMID: 34168138 2021 Nature communications

Result: However, the C14408U mutation in RdRP (P323L) might introduce a novel structure with a smaller apical loop (14,380-14,441 nt).

Evolution, correlation, structural impact and dynamics of emerging SARS-CoV-2 variants.

PMID: 34188776 2021 Computational and structural biotechnology journal

Abstract: Using a combination of bioinformatics and structural analyses, we show that the new SARS-CoV-2 variants emerged in the background of an already known Spike protein mutation D614G together with another mutation P323L in the RNA polymerase of SARS-CoV-2.

SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current Evidence.

PMID: 34203844 2021 Journal of clinical medicine

Result: In a study conducted among 44 Vietnamese patients, 85 mutations covering 67 variant types were reported, of which P323L and D614G variants were the most frequent (present in 40/44 patients), followed by C241U (39/44) and GGG to AAC at 28881-3 variants (33/44).

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