literature

SARS_CoV_2 mutation literature information.

Whole Genome Sequencing of SARS-CoV-2 Strains in COVID-19 Patients From Djibouti Shows Novel Mutations and Clades Replacing Over Time.

PMID: 34540874 2021 Frontiers in medicine

Discussion: About 65.6% of the viruses belong to clades 20A, 20B, and 20C and non-synonymous mutations leading to two amino acid substitutions, the D614G in the spike and P323L in nsp12, were predominant in most countries.

Discussion: It should be noted, the P323L substitution has been frequently observed in nsp12 in the strain spreading in Africa.

Genomic analysis of early transmissibility assessment of the D614G mutant strain of SARS-CoV-2 in travelers returning to Taiwan from the United States of America.

PMID: 34557346 2021 PeerJ

Result: In addition to the S-protein D614G mutation, other missense mutations were identified in NSP12 (RNA dependent RNA polymerase; RdRp) with a P323L mutation, a T85I mutation in

Discussion: Our current findings are consistent with this observation, in that the viral genome sequences of the SARS-CoV-2 strains from Cases 1-4 harbored both the D614G and P323L mutations.

Discussion: Previous studies have shown that the P323L mutation in NSP12 co-evolved with the D614G mutation in S-protein.

SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation.

PMID: 34663909 2021 Cell research

Abstract: Furthermore, NSP12 323L variant, encoded by the SARS-CoV-2 C14408T variant first detected in Lombardy, Italy, that carries a Pro323Leu amino acid substitution in NSP12, showed increased ability to activate RIPK1.

Introduction: In addition, the SARS-CoV-2 viral variants carrying P323L

Result: To determine the functional significance of the differential interaction mediated by the original variant NSP12 323P and NSP12 323L encoded by the C14408T variant with RIPK1, we isolated a virus strain carrying the C14408T (NSP12 P323L) mutation from a patient nasopharyngeal swab.

The evaluation of potential global impact of the N501Y mutation in SARS-COV-2 positive patients.

PMID: 34676574 2021 Journal of medical virology

Table: P323L

Dominant clade-featured SARS-CoV-2 co-occurring mutations reveal plausible epistasis: An in silico based hypothetical model.

PMID: 34676891 2021 Journal of medical virology

Result: P323L mutation of RdRp may change binding affinity to the Ubl1 region of NSP3 (Figure 1).

Result: The S:p.D614G might assist in rapid entry into the host cells followed by quick dissemination, and the RdRp:p:P323L may instead boost the replication by a faster RNA processing (exiting).

Result: Therefore, the P323L mutation within the RdRp interface domain's conserved site may only affect the RdRp-NSP8 interaction without changing metal binding affinity.

Analysis of 329,942 SARS-CoV-2 records retrieved from GISAID database.

PMID: 34735950 2021 Computers in biology and medicine

Discussion: For example, D614G is often considered together with P323L.

Changing predominant SARS-CoV-2 lineages drives successive COVID-19 waves in Malaysia, February 2020 to March 2021.

PMID: 34757638 2021 Journal of medical virology

Result: Nonsynonymous mutations seen in the B.1.524 lineage sequences were nsp3-T1198I, nsp4-T28I, nsp5-T24A, nsp12-P323L, nsp13-L428F, spike-D614G, spike-A701V, and N-S194L.

Discussion: The nsp12 (RNA-dependent RNA polymerase) P323L mutation present in lineage B.1.524 is almost always associated with

PMID: 34764315 2021 Scientific reports

Result: The C14408T was encoded for substitution of proline with leucine at position 323 in nsp12 of ORF1ab (nsp12-P323L).

Table: P323L

An outbreak of SARS-CoV-2 with high mortality in mink (Neovison vison) on multiple Utah farms.

PMID: 34767598 2021 PLoS pathogens

Result: One of the two mink from farm A had mutations at T85I-NSP2, S1205L-NSP3, G37E-NSP9, P323L-NSP12, T91M-NSP15, D614G-spike, N501T-spike, Q57H-NS3, H182Y-NS3, and T205I-N as compared to hCoV-19/Wuhan/WIV04/2019.

Table: P323L

Discussion: Success of the P323L/ G614 variant s

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a Dog in Connecticut in February 2021.

PMID: 34834948 2021 Viruses

Result: The D614G and P323L occurred in China on 24 January 2020 and in the U.K.

Result: The B.1 and its sub-lineages that carry both D614G in spike and P323L in nsp12 substitutions have become the dominant variants across the world.

Result: We found amino acid substitutions in Spike (D614G), N (D377Y, P67S, P199L), NS3 (G172V, Q57H), NS8 (S24L) NSP2 (T85I

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