literature

SARS_CoV_2 mutation literature information.

Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 viruses.

PMID: 34399188 2021 Journal of autoimmunity

Introduction: It was previously reported that D614G and P323L were present in all SARS-CoV-2 sequences by the summer of 2020.

Table: P323L

SARS-CoV-2 reinfection in a healthcare professional in inner Sao Paulo during the first wave of COVID-19 in Brazil.

PMID: 34425504 2021 Diagnostic microbiology and infectious disease

Conclusion: Mutations found only in EPI_ISL_708530 included NSP2 V577F, NSP7 L71F, NSP12 P323L, and NSP16 R216N.

Table: P323L

Emergence and expansion of SARS-CoV-2 B.1.526 after identification in New York.

PMID: 34428777 2021 Nature

Introduction: Non-spike mutations widely shared by B.1.526-E484K and B.1.526-S477N isolates include: T85I in ORF1a-nsp2; L438P in ORF1a-nsp4, a 9-base pair (bp) deletion (Delta106-108) in ORF1a-nsp6; P323L in ORF1b-nsp12; Q88H in ORF1b-nsp13; Q57H in ORF3a; and P199L and M234I in the N<

Novel Nested-Seq Approach for SARS-CoV-2 Real-Time Epidemiology and In-Depth Mutational Profiling in Wastewater.

PMID: 34445204 2021 International journal of molecular sciences

Abstract: A mutational analysis indicated the prevalence of D614G (S) and P323L (RdRP) variants, as well as of the Beta.1.1.7/alpha variant of concern, in agreement with the frequency of Beta.1.1.7/alpha variant in clinical samples of the same period of the third pandemic wave at the national level.

Conclusion: Our analysis indicated the high prevalence of the D614G and P323L missense mutations within S and RdRP genes, respectively; the growing trend of Q57H mutation in ORF3a; and the overrepresentation of R203K with G204R or G204L

Emergence and spread of the potential variant of interest (VOI) B.1.1.519 of SARS-CoV-2 predominantly present in Mexico.

PMID: 34448936 2021 Archives of virology

Table: P323L

Molecular characterization of SARS-CoV-2 from Bangladesh: implications in genetic diversity, possible origin of the virus, and functional significance of the mutations.

PMID: 34458642 2021 Heliyon

Abstract: The P323L was reported to increase mutation rate and D614G is associated with increased viral replication and currently most prevalent variant circulating all over the world.

Abstract: The most frequent mutation that occurred in 98% isolates was 3037C>T which is a synonymous change that usually accompanied 3 other mutations that include 241C>T, 14408C>T (P323L in RdRp) and 23403A>G (D614G in spike protein).

Discussion: The P323L mutation in RdRp is reported to be associated with increased mutation rate.

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.

PMID: 34462752 2021 bioRxiv

Method: Individual point mutations for Alpha (NSP3: P153L, T183I, A890D, I1412T; NSP6: SGF106-108del; NSP12: P323L; Spike: HV69-70del, Y145del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H; ORF8: Q27stop, R52I, Y73C, S84L<

Higher entropy observed in SARS-CoV-2 genomes from the first COVID-19 wave in Pakistan.

PMID: 34464419 2021 PloS one

Result: A GH clade strain from May had L lineage associated mutation (Orf1ab L3606F and P323L) in addition to those typical of its clade.

Discussion: The L84S mutation is common amongst S clade isolates found in Europe where it was found to co-evolve with mutations such as P323L.

Discussion: We observed a GH isolate from May to have Orf1ab L3606F mutation co-occurring with P323L.

Emergence and expansion of highly infectious spike protein D614G mutant SARS-CoV-2 in central India.

PMID: 34518554 2021 Scientific reports

Discussion: Another important amino acid substitution P323L in RNA dependent RNA polymerase (RdRP) protein was recorded in 16 viral strains sequenced in this study.

The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages.

PMID: 34537136 2021 Cell

Introduction: Other than the early identification of the D614G substitution in the viral Spike protein and P323L in the viral RNA-dependent RNA polymerase protein, both of which may have increased viral transmissibility without impacting pathogenesis, few mutations were epidemiologically significant and the evolutionary dynamics of the virus were predominantly characterized by a mutational pattern of slow and selectively neutral random genetic drift.

Figure: Also included for reference are sites previously detected to be evolving under positive selection such as S/614, the site of the D614G mutation that is present in all three of the 501Y lineages, S/5, and RdRp/P323L (ORF1b/

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