literature

SARS_CoV_2 mutation literature information.

The Evolutionary Landscape of SARS-CoV-2 Variant B.1.1.519 and Its Clinical Impact in Mexico City.

PMID: 34834987 2021 Viruses

Discussion: Importantly, they also inferred that the Pro323Leu mutation occurred on an Asp614Gly background.

Discussion: They identified that the Pro323Leu mutation in the RNA-dependent RNA polymerase led to the rapid spread of the virus, rather than the previously reported Asp614Gly mutation in the spike glycoprotein.

The evaluation of potential global impact of the N501Y mutation in SARS-COV-2 positive patients.

PMID: 34676574 2021 Journal of medical virology

Table: P323L

Emergence and expansion of highly infectious spike protein D614G mutant SARS-CoV-2 in central India.

PMID: 34518554 2021 Scientific reports

Discussion: Another important amino acid substitution P323L in RNA dependent RNA polymerase (RdRP) protein was recorded in 16 viral strains sequenced in this study.

The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages.

PMID: 34537136 2021 Cell

Introduction: Other than the early identification of the D614G substitution in the viral Spike protein and P323L in the viral RNA-dependent RNA polymerase protein, both of which may have increased viral transmissibility without impacting pathogenesis, few mutations were epidemiologically significant and the evolutionary dynamics of the virus were predominantly characterized by a mutational pattern of slow and selectively neutral random genetic d

Figure: Also included for reference are sites previously detected to be evolving under positive selection such as S/614, the site of the D614G mutation that is present in all three of the 501Y lineages, S/5, and RdRp/P323L (ORF1b/314).

Whole Genome Sequencing of SARS-CoV-2 Strains in COVID-19 Patients From Djibouti Shows Novel Mutations and Clades Replacing Over Time.

PMID: 34540874 2021 Frontiers in medicine

Discussion: About 65.6% of the viruses belong to clades 20A, 20B, and 20C and non-synonymous mutations leading to two amino acid substitutions, the D614G in the spike and P323L in nsp12, were predominant in most countries.

Discussion: It should be noted, the P323L substitution has been frequently observed in nsp12 in the strain spreading in Africa.

Genomic analysis of early transmissibility assessment of the D614G mutant strain of SARS-CoV-2 in travelers returning to Taiwan from the United States of America.

PMID: 34557346 2021 PeerJ

Result: In addition to the S-protein D614G mutation, other missense mutations were identified in NSP12 (RNA dependent RNA polymerase; RdRp) with a P323L mutation, a T85I mutation in

Discussion: Our current findings are consistent with this observation, in that the viral genome sequences of the SARS-CoV-2 strains from Cases 1-4 harbored both the D614G and P323L mutations.

Discussion: Previous studies have shown that the P323L mutation in NSP12 co-evolved with the D614G mutation in S-protein.

SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation.

PMID: 34663909 2021 Cell research

Abstract: Furthermore, NSP12 323L variant, encoded by the SARS-CoV-2 C14408T variant first detected in Lombardy, Italy, that carries a Pro323Leu amino acid substitution in NSP12, showed increased ability to activate RIPK1.

Introduction: In addition, the SARS-CoV-2 viral variants carrying P323L

Result: To determine the functional significance of the differential interaction mediated by the original variant NSP12 323P and NSP12 323L encoded by the C14408T variant with RIPK1, we isolated a virus strain carrying the C14408T (NSP12 P323L) mutation from a patient nasopharyngeal swab.

Changing predominant SARS-CoV-2 lineages drives successive COVID-19 waves in Malaysia, February 2020 to March 2021.

PMID: 34757638 2021 Journal of medical virology

Result: Nonsynonymous mutations seen in the B.1.524 lineage sequences were nsp3-T1198I, nsp4-T28I, nsp5-T24A, nsp12-P323L, nsp13-L428F, spike-D614G, spike-A701V, and N-S194L.

Discussion: The nsp12 (RNA-dependent RNA polymerase) P323L mutation present in lineage B.1.524 is almost always associated with

PMID: 34767598 2021 PLoS pathogens

Result: One of the two mink from farm A had mutations at T85I-NSP2, S1205L-NSP3, G37E-NSP9, P323L-NSP12, T91M-NSP15, D614G-spike, N501T-spike, Q57H-NS3, H182Y-NS3, and T205I-N as compared to hCoV-19/Wuhan/WIV04/2019.

Table: P323L

Discussion: Success of the P323L/ G614 variant s

Emergence of B.1.524(G) SARS-CoV-2 in Malaysia during the third COVID-19 epidemic wave.

PMID: 34764315 2021 Scientific reports

Result: The C14408T was encoded for substitution of proline with leucine at position 323 in nsp12 of ORF1ab (nsp12-P323L).

Table: P323L