literature

SARS_CoV_2 mutation literature information.

A next generation sequencing (NGS) analysis to reveal genomic and proteomic mutation landscapes of SARS-CoV-2 in South Asia.

PMID: 34841355 2021 Current research in microbial sciences

Table: P323L

Phylogenomics and population genomics of SARS-CoV-2 in Mexico during the pre-vaccination stage reveals variants of interest B.1.1.28.4 and B.1.1.222 or B.1.1.519 and the nucleocapsid mutation S194L associated with symptoms.

PMID: 34846283 2021 Microbial genomics

Result:

Discussion: P323L affects the function of the RNA-dependent RNA polymerase, associated with an increase in mutation rate.

Discussion: A hypothesis - yet to be tested - is that mutations P323L-D614G reinforce the asymptomatic phenotype, at least in a Mexican genetic background.

SARS-CoV-2 genetic variations associated with COVID-19 pathogenicity.

PMID: 34870573 2021 Microbial genomics

Introduction: the mutation P323L in RNA-dependent RNA polymerase protein) and 23 403A>G.

Table: P323L

Mutational landscape of SARS-CoV-2 genome in Turkey and impact of mutations on spike protein structure.

PMID: 34871297 2021 PloS one

Table: Pro323Leu

Spatial epidemiology and genetic diversity of SARS-CoV-2 and related coronaviruses in domestic and wild animals.

PMID: 34910734 2021 PloS one

Abstract: The highest mutations observed in mink where the substitution of D614G in spike (95.2%) and P323L in NSP12 (95.2%) protein.

Result: The D614G in spike protein and P323L in non-structural protein 12 (NSP12) were the most prevalent (95.2%) mutations in minks.

Molecular Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Isolates From Central Inner Sardinia.

PMID: 35095827 2021 Frontiers in microbiology

Discussion: The identification of the specific missense mutations for each gene highlighted how some substitutions are ubiquitous, such as spike D614G and RdRp P4715L (also known as P323L).

Importation, circulation, and emergence of variants of SARS-CoV-2 in the South Indian state of Karnataka.

PMID: 35243004 2021 Wellcome open research

Discussion: The lineage is characterized by the following amino acid replacements- nsp12-P323L(95.38%), S-D614G (93.85%), S-N440K (56.92%), ORF 3a-Q57H (90.77%), ORF 3a-E261*(81.54%), nsp3-T183I (81.54%), nsp16-L126F(80%), N-S2P (72.31%), ORF 8-S97I (72.31%) (extended data, Supplementary Table 7 ).

Omicron: A Heavily Mutated SARS-CoV-2 Variant Exhibits Stronger Binding to ACE2 and Potently Escapes Approved COVID-19 Therapeutic Antibodies.

PMID: 35140714 2021 Frontiers in immunology

Introduction: The non-structural proteins encoded by the ORF1ab contain mutations in the nsp3 (K38R, V1069I, Delta1265, L1266I, A1892T), nsp4 (T492I), nsp5 (P132H), nsp6 (Delta105-107, A189V), nsp12 (P323L), and nsp14 (I42V).

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a Dog in Connecticut in February 2021.

PMID: 34834948 2021 Viruses

Result: The D614G and P323L occurred in China on 24 January 2020 and in the U.K.

Result: The B.1 and its sub-lineages that carry both D614G in spike and P323L in nsp12 substitutions have become the dominant variants across the world.

Result: We found amino acid substitutions in Spike (D614G), N (D377Y, P67S, P199L), NS3 (G172V, Q57H), NS8 (S24L) NSP2 (T85I

SARS-CoV-2 genetic diversity and variants of concern in Saudi Arabia.

PMID: 35044933 2021 Journal of infection in developing countries

Abstract: Risk of death was highest with the NSP12_P323L mutation (OR = 1.84; 95% CI = 0.37-9.30) and lowest with the NS3_Q57H mutation (OR = 0.43; 95% CI = 0.25-0.727).

Abstract: The most common variants detected were the NSP12_P323L mutation 94.9%, followed by the D614G mutation (76%) and the NS3_Q57H mutation (71.4%).

Browser Board

Co-occurred Entities

Filtrator