Discussion: Importantly, they also inferred that the Pro323Leu mutation occurred on an Asp614Gly background.
Discussion: They identified that the Pro323Leu mutation in the RNA-dependent RNA polymerase led to the rapid spread of the virus, rather than the previously reported Asp614Gly mutation in the spike glycoprotein.
A next generation sequencing (NGS) analysis to reveal genomic and proteomic mutation landscapes of SARS-CoV-2 in South Asia.
PMID: 34841355
2021
Current research in microbial sciences
Table: P323L
Phylogenomics and population genomics of SARS-CoV-2 in Mexico during the pre-vaccination stage reveals variants of interest B.1.1.28.4 and B.1.1.222 or B.1.1.519 and the nucleocapsid mutation S194L associated with symptoms.
Discussion: P323L affects the function of the RNA-dependent RNA polymerase, associated with an increase in mutation rate.
Discussion: A hypothesis - yet to be tested - is that mutations P323L-D614G reinforce the asymptomatic phenotype, at least in a Mexican genetic background.
Discussion: Also, as far as we are aware, the association of P323L to severity disease has been only tested in symptomatic patients so ours is the first observation of P323L being associated with an asymptomatic phenotype.
Discussion: The discrete association of both D614G and P323L to an asymptomatic phenotype could mean that those fixed mutations enhance transmissibility by bypassing an immune response.
SARS-CoV-2 genetic variations associated with COVID-19 pathogenicity.
Introduction: In addition, an Nsp12 mutation (P323L) and N protein double mutations (R203K and G204R) were also found.
Discussion: Although it has been found that SARS-CoV-2 with the D614G mutation in the spike protein can replicate and spread faster than strains without this mutation, interestingly, the P323L mutation has been reported to co-evolve with D614G worldwide, this adaptation of the virus might strengthen SARS-CoV-2 G614 strain replication rates and infectivity.
Discussion: In summary, we sequenced and reported the first case of mutations in the genes encoding the spike (D614G) and
The Impact of Mutations on the Pathogenic and Antigenic Activity of SARS-CoV-2 during the First Wave of the COVID-19 Pandemic: A Comprehensive Immunoinformatics Analysis.
Result: D614G (50%) and P323L (49%) mutations showed the highest frequency among the screened sequences.
Result: Another highly prevalent mutation (P323L) in the RdRp region was found to be neutral (score = 2), whereas its infectivity has not been reported so far.
Result: Moreover, the mutation frequencies of P323L (49%) and D614G (50%) were found to be similar within the period from 15 January 2020 to 15 July 2021.
Discussion: A highly mutated amino acid was observed at the position D614G (50%) in the S protein and P323L (49%) in the RdRp protein.
Discussion: Another highly prevalent mutation,
SARS-CoV-2 genetic diversity and variants of concern in Saudi Arabia.
PMID: 35044933
2021
Journal of infection in developing countries
Abstract: Risk of death was highest with the NSP12_P323L mutation (OR = 1.84; 95% CI = 0.37-9.30) and lowest with the NS3_Q57H mutation (OR = 0.43; 95% CI = 0.25-0.727).
Abstract: The most common variants detected were the NSP12_P323L mutation 94.9%, followed by the D614G mutation (76%) and the NS3_Q57H mutation (71.4%).
Molecular Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Isolates From Central Inner Sardinia.
Discussion: The identification of the specific missense mutations for each gene highlighted how some substitutions are ubiquitous, such as spike D614G and RdRp P4715L (also known as P323L).
SARS_CoV_2 mutation literature information.
PMID: 
2021
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