Introduction: Non-spike mutations widely shared by B.1.526-E484K and B.1.526-S477N isolates include: T85I in ORF1a-nsp2; L438P in ORF1a-nsp4, a 9-base pair (bp) deletion (Delta106-108) in ORF1a-nsp6; P323L in ORF1b-nsp12; Q88H in ORF1b-nsp13; Q57H in ORF3a; and P199L and M234I in the N<
SARS-CoV-2 reinfection in a healthcare professional in inner Sao Paulo during the first wave of COVID-19 in Brazil.
PMID: 34425504
2021
Diagnostic microbiology and infectious disease
Conclusion: Mutations found only in EPI_ISL_708530 included NSP2 V577F, NSP7 L71F, NSP12 P323L, and NSP16 R216N.
Table: P323L
Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 viruses.
Introduction: It was previously reported that D614G and P323L were present in all SARS-CoV-2 sequences by the summer of 2020.
Table: P323L
Correlates of SARS-CoV-2 Variants on Deaths, Case Incidence and Case Fatality Ratio among the Continents for the Period of 1 December 2020 to 15 March 2021.
Abstract: The NSP12_P323L and Spike_D614G mutations showed a positive correlation to the number of cases per million.
Abstract: The Spike_D614G and NSP12_P323L mutations showed a positive correlation to deaths per million.
Abstract: The mutations having the highest frequencies among different continents were Spike_D614G and NSP12_P323L.
Discussion: In the current study, the mutations having the highest frequencies among continents were missense, including Spike_D614G and
Conformational Variability Correlation Prediction of Transmissibility and Neutralization Escape Ability for Multiple Mutation SARS-CoV-2 Strains using SSSCPreds.
Introduction: After March 2020, only two mutations, RNA-directed RNA polymerase P323L (ORF1ab P4715L, ORF1b P314L) and spike protein D614G had nearly overwhelmed the original mutation sites ().
Introduction and Characteristics of SARS-CoV-2 in North-East of Romania During the First COVID-19 Outbreak.
Discussion: As a consequence, a synonymous mutation in NSP3, a P323L mutation in RNA primase, and a mutation in spike glycoprotein (614 D > G) occurred.
The architecture of the SARS-CoV-2 RNA genome inside virion.
Result: In a study conducted among 44 Vietnamese patients, 85 mutations covering 67 variant types were reported, of which P323L and D614G variants were the most frequent (present in 40/44 patients), followed by C241U (39/44) and GGG to AAC at 28881-3 variants (33/44).
Evolution, correlation, structural impact and dynamics of emerging SARS-CoV-2 variants.
PMID: 34188776
2021
Computational and structural biotechnology journal
Abstract: Using a combination of bioinformatics and structural analyses, we show that the new SARS-CoV-2 variants emerged in the background of an already known Spike protein mutation D614G together with another mutation P323L in the RNA polymerase of SARS-CoV-2.
Remdesivir MD Simulations Suggest a More Favourable Binding to SARS-CoV-2 RNA Dependent RNA Polymerase Mutant P323L Than Wild-Type.
Result: All these analyses showed that the mutant A97V-RdRp does not have a large effect on RDV binding, in contrast, P323L-RdRp structure has a stabilising effect on RDV binding.
Result: As for the P323L-apo (pink) structure, the RMSD showed a similar profile to the WT until 175 ns, where the structure decreased instability and the RMSD increased to 3.5 A.
Result: As such, the eigenvectors showed that the P323L-RdRp that bound to RDV contributed to a 13% variance in comparison to WT-RdRp and A97V-Rdrp (Figure 6C).
Result: As such, these results suggested that P323L induced a confo
SARS_CoV_2 mutation literature information.
PMID: 
2021
Nature
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