Role of the Microbiome in the Pathogenesis of COVID-19.
PMID: 35433495
2022
Frontiers in cellular and infection microbiology
Introduction: These had two co-evolving NS mutants, which differ in RdRp (P323L) and spike (S) protein (D614G).
Prolonged shedding of infectious viruses with haplotype switches of SARS-CoV-2 in an immunocompromised patient.
PMID: 35430092
2022
Journal of infection and chemotherapy
Discussion: P314L (P323L) had been one of the common mutations in PANGON lineage B, and all seven haplotypes in our study possessed the mutation as the background.
The dynamics of circulating SARS-CoV-2 lineages in Bogor and surrounding areas reflect variant shifting during the first and second waves of COVID-19 in Indonesia.
Result: Notably, a total 199 out of 202 viruses (99.9%) that we sequenced carried the S_D614G and NSP12_P323L non-synonymous mutations.
Figure: One virus (hCoV-19/Indonesia/JK-LIPI135/2021) not shown in this figure was found to carry multiple amino acid changes, including S_D614G, S_P681R, S_T478K, S_L452R, NSP6_T77A, NSP3_P1228L, NSP12_P323L, NSP12_G671S, and NSP14_A394V.
Figure: The highest incidence of sub
Heat Treatment Promotes Ubiquitin-Mediated Proteolysis of SARS-CoV-2 RNA Polymerase and Decreases Viral Load.
Abstract: A mild daily heat treatment maintains low levels of both wild-type and P323L mutant of NSP12, suggesting clinical potential.
Abstract: Here, we reveal a potential mechanism by which mild heat treatment destabilizes the wild-type RNA-dependent RNA polymerase (also known as nonstructural protein 12 (NSP12)) of SARS-CoV-2 as well as the P323L mutant commonly found in SARS-CoV-2 variants, including omicron and IHU.
Intr
Introduction: Although our study lacks adequate evidence obtained from in vivo animal model showing the inhibitory effect of mild heat treatment on the SARS-CoV-2 virulence, we do provide clear evidence that mild daily treatment is sufficient to maintain low levels of both WT and P323L mutant of NSP12.
Coronavirus Genomes and Unique Mutations in Structural and Non-Structural Proteins in Pakistani SARS-CoV-2 Delta Variants during the Fourth Wave of the Pandemic.
Discussion: As a consequence, a synonymous mutation in NSP3, a P323L mutation in RNA primase, and a mutation in spike glycoprotein (614 D > G) occurred.
Conformational Variability Correlation Prediction of Transmissibility and Neutralization Escape Ability for Multiple Mutation SARS-CoV-2 Strains using SSSCPreds.
Introduction: After March 2020, only two mutations, RNA-directed RNA polymerase P323L (ORF1ab P4715L, ORF1b P314L) and spike protein D614G had nearly overwhelmed the original mutation sites ().
Molecular characterization of SARS-CoV-2 from Bangladesh: implications in genetic diversity, possible origin of the virus, and functional significance of the mutations.
Abstract: The P323L was reported to increase mutation rate and D614G is associated with increased viral replication and currently most prevalent variant circulating all over the world.
Abstract: The most frequent mutation that occurred in 98% isolates was 3037C>T which is a synonymous change that usually accompanied 3 other mutations that include 241C>T, 14408C>T (P323L in RdRp) and 23403A>G (D614G in spike protein).
Discussion: The P323L mutation in RdRp is reported to be associated with increased mutation rate.
Discussion: Those mutations inclu
Emergence and spread of the potential variant of interest (VOI) B.1.1.519 of SARS-CoV-2 predominantly present in Mexico.
SARS_CoV_2 mutation literature information.
PMID: 
2022
Frontiers in cellular and infection microbiology
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