Result: (2) An alternative, contrasting, hypothesis is that the Asp614Gly mutation allowed for more efficient host cell entry, but decreased production of virus by the cell and it was only the addition of Pro323Leu nsp12 that enhanced the replication efficiency, resulting in increased production of virus.
Result: (3) It is possible that the Pro323Leu nsp12 led to enhanced transmission simply from increased genome diversity by generating a higher number of mutations, which is supported by our analysis above.
Result: 2) is a Pro323Leu mutation in the RNA-dependent RNA polymerase protein nsp12.
Result: Closer inspection reveals that the nsp12
Full-length genome characterization and phylogenetic analysis of SARS-CoV-2 virus strains from Yogyakarta and Central Java, Indonesia.
Result: Moreover, WGS of virus from patient-1, patient-2 and patient 3 showed nine amino acid mutations in six proteins, including NSP3 (P679S), NSP12 (P323L, A656S), NSP13 (M576I), spike (D614G), NS3 (A54V, Q57H, A99S), and NP (Q160R); four amino acid mutations in four proteins: NSP3 (P822L), NSP12 (P323L), Spike (
Remdesivir MD Simulations Suggest a More Favourable Binding to SARS-CoV-2 RNA Dependent RNA Polymerase Mutant P323L Than Wild-Type.
Result: This mutation results in a missense mutation P4715L at the amino acid level of ORF1ab polyprotein that ultimately appears as P323L mutation in the RdRp enzyme.
Discussion: Although the 14408C>T (RdRp P323L) mutation was predominantly found in severely affected patients in the present study, further studies will be required to elucidate whether this RdRp mutation has any significant impact on the viability and infectivity of SARS-CoV-2 and the severity of COVID-19.
Discussion: Based on our findings, it may be concluded that the spike protein D614G and
The Novel Coronavirus Enigma: Phylogeny and Analyses of Coevolving Mutations Among the SARS-CoV-2 Viruses Circulating in India.
PMID: 33496683
2020
JMIR bioinformatics and biotechnology
8Discussion: The ""major group"" of SARS-CoV-2 strains (66/95, 69.4%) represents the A2a clade reported previo
Discussion: Few strains from Europe and North America since February 2020 have shown the emergence of mutations like 3037C>T (F106F, NSP3), 23403A>G (D614G), and 28881-28883GGG>AAC (R203K and G204R, N) in the SARS-CoV-2 genome harboring the 14408C>T (P323L) mutation within the RdRP gene, suggesting a probable association or coexistence of 14408C>T (P323L) and the emerging higher number of novel point mutations compared to viral genomes from Asia.
SARS_CoV_2 mutation literature information.
PMID: 
2020
Genome biology
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