Emergence of a novel SARS-CoV-2 Pango lineage B.1.1.526 in West Bengal, India.
PMID: 34896696
2022
Journal of infection and public health
Result: By performing the whole genome mutational analysis of 8592 SARS-CoV-2 strains collected during August 2020 to October 2021 from India, we identified 126 SARS-CoV-2 strains having new set of 11 coexisting mutations among 7 different genes: D279N and L353F in NSP4; V26F in NSP8; P323L in NSP12; D614G, P681H and V1230L in S glycoprotein; G172C in NS3; V62L in NS8; and R203K and
Table: P323L
Variants of SARS CoV-2: mutations, transmissibility, virulence, drug resistance, and antibody/vaccine sensitivity.
PMID: 35227008
2022
Frontiers in bioscience (Landmark edition)
Abstract: Mutations in the S protein that are common among several of the variants include D614G that increases transmissibility and viral load and is often associated with P323L on the RNA dependent RNA polymerase.
Versatile SARS-CoV-2 Reverse-Genetics Systems for the Study of Antiviral Resistance and Replication.
Abstract: We found that putative coronavirus remdesivir resistance-associated substitutions F480L and V570L-and naturally found polymorphisms A97V, P323L, and N491S, all in nsp12-did not decrease SARS-CoV-2 susceptibility to remdesivir.
Result: Among natural nsp12 polymorphisms, we investigated the P323L mutation, known as the major polymorphic site of nsp12 (>90% prevalence found in GISAID EpiCov database accessed 10 May 2021).
High diversity in Delta variant across countries revealed by genome-wide analysis of SARS-CoV-2 beyond the Spike protein.
Result: Strikingly, all these mutations except P323L in NSP12 are nearly exclusive to the Delta variant compared to other variants of concern (Alpha, Beta, and Gamma variants of SARS-CoV-2) (mean prevalenceDelta = 99.74%, mean prevalenceotherVariantsofConcern = 0.12%) (Fig EV2, Appendix Table S1).
Result: We identified seven highly prevalent mutations in the following proteins of the Delta variant: Membrane (I82T: 99.9%), Nucleocapsid (R203 M: 99.9%, D377Y: 99.6%), NSP12 (P323L: 99.9%), NS3 (S26L: 99.9%), and NS7a (V82A: 99.4%, T120I<
Genomic characterization unravelling the causative role of SARS-CoV-2 Delta variant of lineage B.1.617.2 in 2nd wave of COVID-19 pandemic in Chhattisgarh, India.
Result: Notably, all variants showed P323L mutation in nonstructural protein (NSP) 12 encoding RNA dependent RNA polymerase (RdRP) gene, and Delta variant exclusively showed I82T mutation in membrane protein-encoding gene.
Table: P323L
Discussion: P323L leads to stability of the tertiary protein structure of the virus to help in virus successful survival in different geographical conditions.
Discussion: All lineages have shown P323L mutation in the interface domain of the RdRP region.
Genetic variations from successive whole genome sequencing during COVID-19 treatment in five individuals.
PMID: 35035981
2022
New microbes and new infections
Introduction: Analysis is also showing mutation within ORF1b at position P314L (P323L) in the initial swab sample in four out of five individuals.
Emergence of two distinct variants of SARS-CoV-2 and an explosive second wave of COVID-19: the experience of a tertiary care hospital in Pune, India.
Result: The Indian Delta variant-specific mutations were G210T (5'UTR) Nsp2-P129L, Result: The Kappa-variant-specific mutations were Nsp3-T749I, Nsp6-T77A (Orf1a), Nsp12-P323L, Nsp13-M429I, Nsp15-K259R (Orf1b), S26L (Orf3a), I33T (Orf6), and V82A (Orf7a).
Longitudinal analysis of SARS-CoV-2 spike and RNA-dependent RNA polymerase protein sequences reveals the emergence and geographic distribution of diverse mutations.
PMID: 34801754
2022
Infection, genetics and evolution
Figure: B) A ribbon diagram of the highly prevalent Nsp12: P323L substitution.
Figure: Most mutations in the polymerase complex do not appear to persist, except for the Nsp12 substitutions P323L, V776L, A185S, and V720I.
Figure: Nearly all mutations besides the Nsp12 substitution P323L have either peaked and subsequently decreased in prevalence, or have plateaued at low prevalence values of 5-10%.
Figure: The combination and prevalence of mutations present varies by continent, with the Nsp12 substitution P323L being most common on all continents, and most other mutations presen
An Update on Severe Acute Respiratory Syndrome Coronavirus 2 Diversity in the US National Capital Region: Evolution of Novel and Variants of Concern.
Result: Of the 93 substitutions that were present in 2020, 61 were no longer present during March 2021 (Figure 5C), and only 8 were present in >5% of samples during March 2021 (NSP2:T85I, NSP12:P323L, S:L5F, S:D614G, NS3aQ57H, NS8:S24L, N
Discussion: This lineage shows amino acid substitutions NSP12:P323L, N:S194L,S:D614G, and S:P681H in >90% of specimens.
SARS-CoV-2 outbreak in Iran: The dynamics of the epidemic and evidence on two independent introductions.
PMID: 33835709
2022
Transboundary and emerging diseases
Table: P323L
Discussion: Variation tracking of SARS-CoV-2 has shown that some mutations:such as P323L and D614G:are distributed globally, while some others are accumulated in specific geographical regions (Kannan et al., 2020).
SARS_CoV_2 mutation literature information.
PMID: 
2022
Journal of infection and public health
Browser Board
Co-occurred Entities
Filtrator
ViMRT