literature

SARS_CoV_2 mutation literature information.

Community-level SARS-CoV-2 sequence diversity revealed by wastewater sampling.

PMID: 34438144 2021 The Science of the total environment

Table: P26S

An Autochthonous Outbreak of the SARS-CoV-2 P.1 Variant of Concern in Southern Italy, April 2021.

PMID: 34449757 2021 Tropical medicine and infectious disease

Introduction: These amino acid changes are L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, and V1176F.

Predominance of the SARS-CoV-2 Lineage P.1 and Its Sublineage P.1.2 in Patients from the Metropolitan Region of Porto Alegre, Southern Brazil in March 2021.

PMID: 34451453 2021 Pathogens (Basel, Switzerland)

Result: Fifteen substitutions (10 in the spike protein: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, and T1027I) are P.1 lineage-defining mutations (Figure 1B and Table 2).

Discussion: The VOC P.1 carries three deletions, four synonymous substitutions, a four base-pair nucleotide insertion, and at least 17 other lineage-defining replacements, including 10 missense mutations in the spike protein (L18F, T20N, P26S, D138Y,

Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants.

PMID: 34465019 2021 mBio

Table: P26S

In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2.

PMID: 34534263 2021 PLoS pathogens

Method: We used the following amino acids replacements and deletions in Spike for each lineage-based COG-UK defined changes for each lineage; Beta (B1.351; L18F, D80A, D215G, R246L, K417N, E484K, N501Y, A701V), Gamma (P.1; L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y H655Y, T1027I), Alpha (B.1.1.7; Delta69-70, D144,

PMID: 34536797 2021 Virology

Result: Few NTD mutations, namely T20N, P26S, D138Y, and R190S, likely contributed to the increase in ACE2 binding, with ~2, ~1.6, ~1.3 and ~1.8- fold increase compared to D614G, respectively.

Result: In the P.1 Spike we observed mutations in the NTD that decreased recognition (P26S, D138Y, and R190S).

Result: Our results show that all the NTD mutations, namely L18F, T20N, P26S, D138Y and R190S, attenuated the binding of naive-vaccinated plasma Abs.

Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants.

PMID: 34549975 2021 Journal of virology

Table: P26S

Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions.

PMID: 34599175 2021 Nature communications

Result: Furthermore, B.1.620 contains P26S, HV69/70Delta, V126A, Y144Delta, LLA241/243Delta and H245Y in the N-terminal domain (NTD) of the spike protein.

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