literature

SARS_CoV_2 mutation literature information.

SARS-CoV-2 Mutations and COVID-19 Clinical Outcome: Mutation Global Frequency Dynamics and Structural Modulation Hold the Key.

PMID: 35386683 2022 Frontiers in cellular and infection microbiology

Introduction: reported P25L mutation in the Orf3a region to be strongly associated with higher mortality rates as a result of structural modification including the acquisition of escalated antigen diversity and B-cell epitope loss.

Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage.

PMID: 35396511 2022 Nature communications

Result: Additional substitutions include P25L (in ~43% of viruses) and W152R (in ~7%) in the NTD, T478K (~17%) in the RBM, L585F (~17%) in S1, P681H (~8%) adjacent to the furin cleavage site, A879T (~7%), D936H (~5%), and H1101Q (~8%) in S2, with additional amino acid changes detected in less than 5% of viruses.

Result: Furthermore, the C136F mutation abolishes a disulfide bond within the N1 loop of NTD, and in combination with P25L likely contributes to immune escape by conformationally liberating the entire N-terminus of the NTD.

Figure: Key mutations known/predicted to influence neutralization sen

Variations in Orf3a protein of SARS-CoV-2 alter its structure and function.

PMID: 33527091 2021 Biochemistry and biophysics reports

Table: P25L

SARS-CoV-2 mutations: the biological trackway towards viral fitness.

PMID: 33928885 2021 Epidemiology and infection

Table: P25L

Emerging mutation in SARS-CoV-2 spike: Widening distribution over time in different geographic areas.

PMID: 34271250 2021 Biomedical journal

Result: In addition, there were mutation types that have more than one case such as in Asia, the mutations A829T (n = 3), P25L (n = 2), V367F (n = 2), R682Q (n = 2), S13I (n = 2), and T22I (n = 2) while the other types have just one case.

Table: P25L

Figure: (A) D614 Mutation (B) A829T (C) E96G and (D) P25L Mutation.

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