Result: Based on the results described above, because 3CLpro has been well characterized as a critical function for viral replication by biochemical and pharmacological analyses, and because the phylogenic tree analysis in Japan showed that the Pro151Leu mutation in nucleocapsid protein occurred earlier than the Pro108Ser mutation.
Result: Of the six mutations, four were non-synonymous: c.4346 U > C (Ser543Pro in papain-like protease [PLpro]), c.10376 C > U (Pro108Ser in 3CLpro), c.14708 C > U (Ala423Val in RNA-dependent RNA polymerase [RdRp]), and c.28725 C > U (Pro151Leu in nucleocapsid protein); the remaining two other mutations did not
Molecular characterization and the mutation pattern of SARS-CoV-2 during first and second wave outbreaks in Hiroshima, Japan.
Abstract: Comparing the first- and second-wave GR strains, mutation rate was 1.17-1.36 x 10-3 base substitutions per site per year; in addition, amino acid changes occurred at S1361P and P3371S in ORF1a, A314V in ORF1b, and P151L in N.
E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil.
PMID: 34044192
2021
Infection, genetics and evolution
Result: New specific single substitutions (S:A27V, N:T16M, N:P151L, N:A267V, Nsp13:T216N, and Nsp14:P443S) were also evaluated.
Diagnostic pre-screening method based on N-gene dropout or delay to increase feasibility of SARS-CoV-2 VOC B.1.1.7 detection.
PMID: 34464903
2021
Diagnostic microbiology and infectious disease
Result: The P151L mutation was detected in only one sample.
Microsecond molecular dynamics suggest that a non-synonymous mutation, frequently observed in patients with mild symptoms in Tokyo, alters dynamics of the SARS-CoV-2 main protease.
Introduction: Their phylogenetic analysis identified four non-synonymous mutations in the viral genome sequence inversely correlated with COVID-19 severity, and subsequent sequence comparison and structure-based prediction suggested that two mutations, P108S and P151L, in the main protease and the nucleocapsid protein, respectively, contribute to a milder clinical course of COVID-19.
SARS-CoV-2 genetic variations associated with COVID-19 pathogenicity.
SARS_CoV_2 mutation literature information.
PMID: 
2022
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